利用空间冗余和局部重构提高数字微流控生物芯片的良率
Yield Enhancement of Digital Microfluidics-Based Biochips Using Space Redundancy and Local Reconfiguration
摘要：
随着基于微流体的生物芯片变得越来越复杂，制造良率将对生产量和产品成本产生重大影响。我们提出了一种间隙冗余的方法，以提高产量的生物芯片，是基于液滴为基础的微流体。在这种设计方法中，备用细胞被放置在微流体阵列内的间隙位点中，并且它们通过局部重新配置来替换相邻的故障细胞。建议的设计方法进行评估，使用一组并发的现实生活中的生物测定。
英文摘要：
As microfluidics-based biochips become more complex, manufacturing yield will have significant influence on production volume and product cost. We propose an interstitial redundancy approach to enhance the yield of biochips that are based on droplet-based microfluidics. In this design method, spare cells are placed in the interstitial sites within the microfluidic array, and they replace neighboring faulty cells via local reconfiguration. The proposed design method is evaluated using a set of concurrent real-life bioassays.
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