镁（II）-八碳硼烷基（己硫基）四氮杂卟啉嵌入脂质体的物理化学研究
Insertion of a magnesium(II)-octacarboranyl(hexylsulfanyl) porphyrazine into liposomes: a physico-chemical study
摘要：
本文报道了一种新型的碳硼烷基四氮杂卟啉镁配合物，即[2，3，7，8，1,2，13，17，18-octagis-（1，2-dicarba-closo-dodecaboranyl）-hexylthio-5，10，15，20-pyrrazine]镁配合物，MgHECSPz的合成、表征和脂质体插入。MgHECSPz旨在提高多途径抗癌治疗的潜力。制备具有不同表面电荷的脂质体制剂作为递送剂。通过DLS、SAXS、SANS和电位测量表征所获得的负载载体，以确定负载脂质体的总体性质和结构细节。
英文摘要：
The synthesis, characterization and liposome insertion of a novel magnesium(II) carboranyl-porphyrazine, i.e. [2,3,7,8,12,13,17,18-octakis- (1,2-dicarba-closo-dodecaboranyl)-hexylthio-5,10,15,20- porphyrazine]magnesium(II) complex, MgHECSPz, is described. MgHECSPz was designed to improve the potentiality in multiple approach anticancer therapy. Liposomal formulations with different surface charge were prepared as delivering agents. The obtained loaded vectors were characterized by DLS, SAXS, SANS and ζpotential measurements in order to define the overall properties and structural details of loaded liposomes.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
