八碳硼烷基卟啉脂质体的小角散射和Zeta电位
Small Angle Scattering and Zeta Potential of Liposomes Loaded with Octa(carboranyl)porphyrazine
摘要：
在这项工作中的物理化学表征的脂质体装载新合成的碳硼烷基四氮杂卟啉（H2HECASPz）进行了描述。该分子代表了用于不同抗癌疗法的潜在药物，例如硼中子捕获疗法、光动力疗法和光热疗法。测试了不同的加载方法和不同的脂质混合物。通过小角散射（SANS和SAXS）、光散射和zeta电位研究了相应的负载载体。在不同的长度尺度和测量的表面电荷的结构数据的组合分析允许获得详细的表征所调查的系统。相关的物理化学参数（大小，多分散性和电荷）的发病机制的差异也进行了严格的讨论。
英文摘要：
In this work the physicochemical characterization of liposomes loaded with a newly synthesised carboranyl porphyrazine (H2HECASPz) is described. This molecule represents a potential drug for different anticancer therapies, such as Boron Neutron Capture Therapy, Photodynamic Therapy and Photothermal Therapy. Different loading methods and different lipid mixtures were tested. The corresponding loaded vectors were studied by Small Angle Scattering (SANS and SAXS), light scattering and zeta potential. The combined analysis of structural data at various length scales and the measurement of the surface charge allowed to obtain a detailed characterization of the investigated systems. The mechanisms underlying the onset of differences in relevant physicochemical parameters (size, polydispersity and charge) were also critically discussed.
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