大分子在核孔复合体中的扩散
Diffusion of Macromolecules across the Nuclear Pore Complex
摘要：
核孔复合物（NPC）是非常有选择性的过滤器，监测细胞质和核质之间的运输。对于NPC的插头，已经提出了两种模型。它们是（i）它是可逆水凝胶或（ii）它是聚合物刷。我们提出了一个介观模型的蛋白质运输通过插头，这是一般足以涵盖两者。蛋白质拉伸塞子并产生局部变形。这样产生的气泡（prtoein+变形）在塞子中执行随机行走。我们发现，对于更快的凝胶松弛，气泡的扩散更大。此外，在使用适当的参数为刷，我们发现，扩散系数低得多。因此，凝胶模型似乎更有可能解释塞子的工作原理。
英文摘要：
Nuclear pore complexes (NPCs) are very selective filters that monitor the transport between the cytoplasm and the nucleoplasm. Two models have been suggested for the plug of the NPC. They are (i) it is a reversible hydrogel or (ii) it is a polymer brush. We propose a mesoscopic model for the transport of a protein through the plug, that is general enough to cover both. The protein stretches the plug and creates a local deformation. The bubble so created (prtoein+deformation) executes random walk in the plug. We find that for faster relaxation of the gel, the diffusion of the bubble is greater. Further, on using parameters appropriate for the brush, we find that the diffusion coefficient is much lower. Hence the gel model seems to be more likely explanation for the workings of the plug.
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