T细胞活化中“短期”生化记忆起源的计算研究
Computational investigations into the orgins of 'short term' biochemical memory in T cell activation
摘要：
最近的研究报道，T细胞可以在与抗原呈递细胞（APC）的中断相遇之间整合信号，使得信号整合的过程表现出一种形式的记忆。在这里，我们使用T细胞激活的简单数学模型进行了计算研究，以研究T细胞-APC接触中断对信号整合的影响。我们认为，在这些时间尺度上的信号整合可能实现的几种机制，并得出结论，立即早期基因产物（IEG）的反馈控制似乎是一个非常合理的机制，允许有效的信号整合和细胞因子的生产从多次暴露于APC。这些计算机模拟分析提供了一个实验路线图，涉及几个可测试的预测。
英文摘要：
Recent studies have reported that T cells can integrate signals between interrupted encounters with Antigen Presenting Cells (APCs) in such a way that the process of signal integration exhibits a form of memory. Here, we carry out a computational study using a simple mathematical model of T cell activation to investigate the ramifications of interrupted T cell-APC contacts on signal integration. We consider several mechanisms of how signal integration at these time scales may be achieved and conclude that feedback control of immediate early gene products (IEGs) appears to be a highly plausible mechanism that allows for effective signal integration and cytokine production from multiple exposures to APCs. Analysis of these computer simulations provides an experimental roadmap involving several testable predictions.
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