arXiv 2109.129012021-09-27q-bio.MN

Information transmission in a two-step cascade: Interplay of activation and repression

Tuhin Subhra Roy, Mintu Nandi, Ayan Biswas, Pinaki Chaudhury, Suman K Banik

备注：: 10 pages, 4 figures

英文摘要：

We present an information-theoretic formalism to study signal transduction in four architectural variants of a model two-step cascade with increasing input population. Our results categorize these four types into two classes depending upon the effect played out by activation and repression on mutual information, net synergy, and signal-to-noise ratio. Within the Gaussian framework and using the linear noise approximation, we derive the analytic expressions for these metrics to establish their underlying relationships in terms of the biochemical parameters. We also verify our approximations through stochastic simulations.

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