转录调控中的信息流与优化
Information flow and optimization in transcriptional control
摘要：
在最简单的转录调控观点中，基因的表达通过转录因子（TF）浓度的变化而开启或关闭。我们使用最近的数据噪音水平在基因表达表明，它应该是可能的传输远远不止一个监管位。实现这种最佳的信息容量将需要由细胞使用的TF浓度的动态范围、调节模块的输入/输出关系以及结合和转录的噪声水平满足一定的匹配关系。这个无参数的预测与最近在早期果蝇胚胎中Bicoid/Hunchback系统的实验非常一致，并且该系统实现了其理论最大信息传输的90%。
英文摘要：
In the simplest view of transcriptional regulation, the expression of a gene is turned on or off by changes in the concentration of a transcription factor (TF). We use recent data on noise levels in gene expression to show that it should be possible to transmit much more than just one regulatory bit. Realizing this optimal information capacity would require that the dynamic range of TF concentrations used by the cell, the input/output relation of the regulatory module, and the noise levels of binding and transcription satisfy certain matching relations. This parameter-free prediction is in good agreement with recent experiments on the Bicoid/Hunchback system in the early Drosophila embryo, and this system achieves ~90% of its theoretical maximum information transmission.
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