插层分子诱导DNA熵弹性的转变
Transition on the entropic elasticity of DNA induced by intercalating molecules
摘要：
我们利用光镊对DNA分子与药物柔红霉素和溴化乙锭相互作用时的拉伸实验进行了研究。这些实验是在从零到2 pN的低力状态下进行的。我们的研究结果表明，DNA-药物复合物的持续长度增加强烈的药物浓度增加到某个临界值。在此临界值以上，持续长度突然减小，并在较大的药物浓度下几乎保持不变。分子的轮廓长度随药物浓度的增加而单调增加并达到饱和。测得的插入剂的持久性长度过渡的临界浓度与报道的DNA-药物复合物的螺旋-卷曲过渡的值一致，从沉降实验中获得。
英文摘要：
We use optical tweezers to perform stretching experiments on DNA molecules when interacting with the drugs daunomycin and ethidium bromide, which intercalate the DNA molecule. These experiments are performed in the low-force regime from zero up to 2 pN. Our results show that the persistence length of the DNA-drug complexes increases strongly as the drug concentration increases up to some critical value. Above this critical value, the persistence length decreases abruptly and remains practically constant for larger drug concentrations. The contour length of the molecules increases monotonically and saturates as drugs concentration increases. Measured in- tercalants critical concentrations for the persistence length transition coincide with reported values for the helix-coil transition of DNA-drug complexes, obtained from sedimentation experiments.
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