Agentic Discovery of Non-Canonical Antimicrobial Peptides with AMPGAN v3
AMPGAN v3 的非经典抗菌肽智能发现
机构 * University of Vermont(弗吉尼亚大学) ; Larner College of Medicine, University of Vermont(弗吉尼亚大学医学学院) ; Purdue University(普渡大学) ; Department of Comparative Pathobiology(比较病理科部门) ; Department of Horticulture and Landscape Architecture(园艺与景观建筑部门) ; Department of Industrial and Molecular Pharmaceutics(工业与分子药学部门)
AI总结 提出 AMPGAN v3,一种多目标条件 GAN,扩展生成词汇至 D-氨基酸和末端修饰,通过双判别器提升稳定性,体外验证显示对革兰氏阳性菌有活性,并引入 PepCraft 多智能体框架用于端到端发现。
Comments Presented at the GenBio Workshop, ICML 2026