Querying structural and functional niches on spatial transcriptomics data
查询空间转录组数据中的结构和功能生态位
机构 * MOE Key Laboratory of Bioinformatics and Bioinformatics Division of BNRIST, Department of Automation, Tsinghua University(生物信息学教育部重点实验室和北京理工大学生物信息学分部,自动化系,清华大学) ; Center for Synthetic and Systems Biology, School of Life Sciences and School of Medicine, Tsinghua University(合成与系统生物学中心,生命科学学院和医学学院,清华大学) ; Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College(胸外科部门,国家癌症中心/国家癌症临床研究中心/癌症医院,中国医学科学院和北京协和医学院) ; Peking Union Medical College, Chinese Academy of Medical Sciences(北京协和医学院,中国医学科学院) ; Biomedical Pioneering Innovation Center (BIOPIC), Peking University(生物医学前瞻性创新中心(BIOPIC),北京大学) ; Cancer Research UK Cambridge Institute, University of Cambridge(英国癌症研究Cambridge研究所,剑桥大学) ; Department of Immunology, School of Basic Medical Sciences, Harbin Medical University(免疫学部门,基础医学学院,哈尔滨医科大学) ; Zhongguancun Academy, Beijing, China(中关村学院,北京,中国) ; Zhongguancun Institute of Artificial Intelligence, Beijing, China(中关村人工智能研究院,北京,中国)
AI总结 提出QueST方法,通过子图建模和对比学习查询空间转录组样本中的相似生态位,有效捕捉异质环境中的生态位结构并跨平台泛化。