2608.21448
2026-08-25
q-bio.GN
cs.LG
新提交
60%
DNA Methylation Profiling in Melanoma: From Lesion Classification to Therapeutic Stratification
黑色素瘤中的DNA甲基化谱分析:从病变分类到治疗分层
Jana T. Winterstein, Lukas Heinlein, Günter Raddatz, Carina Nogueira Garcia, Sarah Haggenmüller, Christoph Wies, Lucas Schneider, Annemarie Hoffsommer, Tim J. Zeuner, Friedegund Meier, Sarah Hobelsberger, Frank F. Gellrich, Mildred Sergon, Axel Hauschild, Lucie Heinzerling, Justin G. Schlager, Kamran Ghoreschi, Max Schlaak, Franz J. Hilke, Carola Berking, Markus V. Heppt, Michael Erdmann, Sebastian Haferkamp, Konstantin Drexler, Dirk Schadendorf, Wiebke Sondermann, Matthias Goebeler, Bastian Schilling, Daniel B. Lipka, Stefan Fröhling, Felix Sahm, Jakob N. Kather, Yuri Tolkach, Jochen S. Utikal, Benjamin Izar, Yevgeniy R. Semenov, Titus J. Brinker
专题命中
医学影像
:diagnosis(abstract);分类 cs.LG、q-bio
AI总结
本研究基于1001份组织样本,用Illumina Infinium MethylationEPIC芯片分析DNA甲基化,构建CpG分类器区分黑素细胞痣、非侵袭性与侵袭性黑色素瘤,还构建生物学导向特征模型预测治疗分组,证实甲基化可作为诊断和治疗分层的生物标志物。