scE2TM improves single-cell embedding interpretability and reveals cellular perturbation signatures
scE2TM提升了单细胞嵌入的可解释性并揭示了细胞扰动特征
机构 * School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou, China(中山大学计算机科学与工程学院) ; School of Computer Science, McGill University, Montreal, Canada(麦吉尔大学计算机科学学院) ; Department of Biomedical Informatics, Harvard Medical School, Boston, USA(哈佛医学院生物医学信息学系) ; School of Science and Technology, Hong Kong Metropolitan University, Hong Kong, China(香港 metropolitan 大学科学与技术学院) ; Department of Computing, The Hong Kong Polytechnic University, Hong Kong, China(香港理工大学计算系)
专题命中 知识编辑与模型理解 :foundation model(abstract);分类 cs.LG
AI总结 scE2TM通过外部知识引导的嵌入式主题模型提升单细胞嵌入的可解释性,揭示细胞扰动特征和生物通路一致性。