Freeze, Diffuse, Decode: Geometry-Aware Adaptation of Pretrained Transformer Embeddings for Antimicrobial Peptide Design
冻结、扩散、解码:面向抗菌肽设计的预训练Transformer嵌入的几何感知适应
Pankhil Gawade, Adam Izdebski, Myriam Lizotte, Kevin R. Moon, Jake S. Rhodes, Guy Wolf, Ewa Szczurek
机构
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Institute of AI for Health, Helmholtz Munich School of Computation, Information
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Technology, Technical University of Munich Mila - Quebec AI institute
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Univ. de Montreal Dept. Mathematics \& Statistics, Utah State University Department of Statistics, Brigham Young University Faculty of Mathematics, Informatics
Comments37 pages, 9 figures; Replaced to match accepted JCAP version. New version contains small editorial changes throughout in response to referee comments, no changes to results
Swarms of Large Language Model Agents for Protein Sequence Design with Experimental Validation
大规模语言模型代理群组用于蛋白质序列设计的实验验证
Fiona Y. Wang, Di Sheng Lee, David L. Kaplan, Markus J. Buehler
机构
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Laboratory for Atomistic and Molecular Mechanics (LAMM), Department of Biological Engineering, Massachusetts Institute of Technology(原子分子力学实验室(LAMM),生物工程系,麻省理工学院)
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Department of Biomedical Engineering, Tufts University(生物医学工程系,塔夫茨大学)
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Laboratory for Atomistic and Molecular Mechanics (LAMM), Department of Civil and Environmental Engineering, Department of Mechanical Engineering, Center for Computational Science and Engineering, Schwarzman College of Computing, Massachusetts Institute of Technology(原子分子力学实验室(LAMM),土木与环境工程系,机械工程系,计算科学与工程中心,计算机科学学院,麻省理工学院)
Comments16 pages, 6 Figures, 2 Tables, submitted to Marine Mammal Science as part of a special issue on Machine Learning and Artificial Intelligence in Marine Mammal Research