门控障碍的解决方案
A Solution to the Gating Paradox
摘要：
我们介绍了一个马尔可夫模型的门控膜通道。该模型的特点是一个可能的解决方案，所谓的门控电流悖论，即钟形曲线，描述的动力学的电压依赖性比预期的更广泛，并转移相对于，S形曲线，描述的电压依赖性的激活。该模型还预测了这种转变的一些温度依赖性，但后者的存在还没有被实验测试到目前为止。
英文摘要：
We introduce a Markov model for the gating of membrane channels. The model features a possible solution to the so-called gating current paradox, namely that the bell-shaped curve that describes the voltage dependence of the kinetics is broader than expected from, and shifted relative to, the sigmoidal curve that describes the voltage dependence of the activation. The model also predicts some temperature dependence of this shift, but presence of the latter has not been tested experimentally so far.
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