应用于活细胞的约翰逊-肯德尔-罗伯茨理论
Johnson-Kendall-Roberts theory applied to living cells
摘要：
Johnson-Kendall-Roberts（JKR）理论是一种精确的软微变形材料强粘附能模型。关于这个理论在诸如活细胞等复杂系统上的有效性，人们知之甚少。我们已经解决了这个问题，使用消耗控制的细胞粘附和测量所需的力分离细胞与微量移液管技术。我们表明，细胞骨架可以提供细胞的三维结构，是足够的弹性，并具有足够低的变形能力的JKR理论是有效的。当细胞骨架被破坏时，JKR理论不再适用。
英文摘要：
Johnson-Kendall-Roberts (JKR) theory is an accurate model for strong adhesion energies of soft slightly deformable material. Little is known about the validity of this theory on complex systems such as living cells. We have addressed this problem using a depletion controlled cell adhesion and measured the force necessary to separate the cells with a micropipette technique. We show that the cytoskeleton can provide the cells with a 3D structure that is sufficiently elastic and has a sufficiently low deformability for JKR theory to be valid. When the cytoskeleton is disrupted, JKR theory is no longer applicable.
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