188 Re代谢放射治疗的小动物显像初步研究
Preliminary study of metabolic radiotherapy with 188Re via small animal imaging
摘要：
188 Re是一种β（Emax = 2.12 MeV）和γ（155 keV）发射体。由于其化学性质与大量使用的示踪剂99 mTc相似，因此透明质酸（HA）分子已被188 Re标记以产生靶向特异性放射性药物。将放射性标记的化合物静脉注射到健康小鼠中，几分钟后能够积聚到肝脏中。为了研究代谢放射治疗对小鼠的影响，我们建立了一个基于YAP：Ce晶体矩阵的小型伽马相机，像素为0.6x0.6x10 mm**3，由R2486 Hamamatsu PSPMT读取。在YAP矩阵的前面放置一个高灵敏度的20 mm厚的平行孔准直器，孔径为1.5 mm，隔片为0.18 mm。本文介绍了用含有188 Re溶液的各种模型和用188 Re-HA溶液注射的C57黑小鼠获得的初步结果。为了提高空间分辨率并同时获得两个正交投影，我们正在平行建造两个新的摄像机，以90度定位。它们使用由H8500 Hamamatsu Flat panel PMT读取的1x 1x 5 mm**3像素CsI（Tl）矩阵。
英文摘要：
188Re is a beta- (Emax = 2.12 MeV) and gamma (155 keV) emitter. Since its chemistry is similar to that of the largely employed tracer, 99mTc, molecules of hyaluronic acid (HA) have been labelled with 188Re to produce a target specific radiopharmaceutical. The radiolabeled compound, i.v. injected in healthy mice, is able to accumulate into the liver after a few minutes. To study the effect of metabolic radiotherapy in mice, we have built a small gamma camera based on a matrix of YAP:Ce crystals, with 0.6x0.6x10 mm**3 pixels, read out by a R2486 Hamamatsu PSPMT. A high-sensitivity 20 mm thick lead parallel-hole collimator, with hole diameter 1.5 mm and septa of 0.18 mm, is placed in front of the YAP matrix. Preliminary results obtained with various phantoms containing a solution of 188Re and with C57 black mice injected with the 188Re-HA solution are presented. To increase the space resolution and to obtain two orthogonal projections simultaneously we are building in parallel two new cameras to be positioned at 90 degrees. They use a CsI(Tl) matrix with 1x1x5 mm**3 pixels read out by H8500 Hamamatsu Flat panel PMT.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
