起搏心肌细胞电压和钙离子的耦合动力学
Coupled dynamics of voltage and calcium in paced cardiac cells
摘要:
我们调查的数值和分析的跨膜电压和细胞内钙循环的耦合动力学起搏的心脏细胞使用一个详细的生理模型,并减少到一个三维离散地图。结果提供了一个理论框架来解释各种实验观察到的模式的不稳定性,从机电一致和不一致的交替准周期振荡的电压和钙。
英文摘要:
We investigate numerically and analytically the coupled dynamics of transmembrane voltage and intracellular calcium cycling in paced cardiac cells using a detailed physiological model and its reduction to a three-dimensional discrete map. The results provide a theoretical framework to interpret various experimentally observed modes of instability ranging from electromechanically concordant and discordant alternans to quasiperiodic oscillations of voltage and calcium.
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