A Microscopic Mechanism for Muscle's Motion

A plausible mechanism of muscle stabilization in stall conditions

We address the well-known limitation of the Huxley and Simmons 1971 (HS) model. It is a statement that at physiological value of stiffness in the actomyosin complex, the distribution of the myosin motors becomes microscopically uniform (all the motors are either in pre- or post-power stroke conformation) after an infinitesimal displacement from the stall (isometric contractions) conditions. Such uniform behavior at the fiber level would generate a negative slope in the $T_2-δ$ relationship (in the nomenclature of the HS paper), not observed experimentally. This negative slope means inhomogenei…

无外部扭矩下软体滚动运动的力学机制

Mechanics of soft-body rolling motion without external torque

本研究揭示果蝇幼虫滚动并非由重力与地面反作用力失衡驱动，而是轴向肌肉序贯激活所致，建立了相关力学模型并通过气动软体机器人验证，为神经回路研究和软体机器人应用提供参考。

基于深度学习的心脏运动电性心律失常电路预测：一项在体计算机模拟研究

Deep Learning-based Prediction of Electrical Arrhythmia Circuits from Cardiac Motion: An In-Silico Study

本研究通过计算机模拟，利用深度学习从心室变形力学预测三维电波动力学，证明该方法能重建复杂心律失常模式，并具有跨方法泛化能力，为无创心律失常诊断提供新途径。

Sliding Mechanism for Actin Myosin System

Based on the Stochastic Inclined Rods Model (SIRM) proposed by H. Matsuura and M. Nakano, we study the microscopic motion of actin myosin system including the motion of the G-actin. Our model is composed of an inclined spring (rod), a myosin head, a myosin filament and G-actins. We discuss the stochastic resonance between the myosin head and random noise. The results of calculation show that the model can convert the random motion to one directional motion, and the myosin head works as a resonator of random noise which absorbs the energy through the stochastic resonance. The intermolecular pot…

Using Surface-Motions for Locomotion of Microscopic Robots in Viscous Fluids

Microscopic robots could perform tasks with high spatial precision, such as acting in biological tissues on the scale of individual cells, provided they can reach precise locations. This paper evaluates the feasibility of in vivo locomotion for micron-size robots. Two appealing methods rely only on surface motions: steady tangential motion and small amplitude oscillations. These methods contrast with common microorganism propulsion based on flagella or cilia, which are more likely to damage nearby cells if used by robots made of stiff materials. The power potentially available to robots in tis…