脊髓内钙动力学分析及其对放电神经元可塑性的影响
Analysis of the intraspinal calcium dynamics and its implications on the plasticity of spiking neurons
摘要：
钙离子通过N-甲基-D-天冬氨酸（NMDA）通道流入树突棘被认为是各种形式的突触可塑性的主要触发因素。在本文中，作者分析计算的平均值的钙瞬变引起的尖峰神经元经历一个简单的模型的离子电流和反向传播的动作电位。这些瞬变的相对可变性，由于突触传递的随机性，被进一步认为是使用一个简单的马尔可夫模型的NMDA receptos。人们发现，这两个平均值和变异性取决于前和突触后动作电位之间的时间。这些结果可能对突触可塑性曲线的预期形式产生影响，并可以形成一个统一的理论尖峰时间依赖性和基于速率的可塑性的基础。
英文摘要：
The influx of calcium ions into the dendritic spines through the N-metyl-D-aspartate (NMDA) channels is believed to be the primary trigger for various forms of synaptic plasticity. In this paper, the authors calculate analytically the mean values of the calcium transients elicited by a spiking neuron undergoing a simple model of ionic currents and back-propagating action potentials. The relative variability of these transients, due to the stochastic nature of synaptic transmission, is further considered using a simple Markov model of NMDA receptos. One finds that both the mean value and the variability depend on the timing between pre- and postsynaptic action-potentials. These results could have implications on the expected form of synaptic-plasticity curve and can form a basis for a unified theory of spike time-dependent, and rate based plasticity.
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