皮质丘脑反馈控制皮质速度调谐吗?
Does Corticothalamic Feedback Control Cortical Velocity Tuning?
摘要:
丘脑是进入皮层的主要通道,其对皮层感受野特性的贡献已得到充分证实。反过来,对丘脑的皮质反馈是对中继细胞的解剖学上占主导地位的输入,但它对丘脑处理的影响一直难以解释。为了理解复杂的感觉处理,皮质丘脑相互作用的详细概念还需要建立。为了研究corticogeniculate处理模型中,我们利用各种生理和解剖数据的内在动力学的膝状体中继神经元,皮质的影响中继模式,滞后和nonlagged神经元,和视觉皮层感受野的结构。在广泛的计算机模拟中,我们阐述了新的假设,即视觉皮层通过反馈控制膝状体中继细胞的时间响应特性,从而改变皮层细胞的速度调谐。
英文摘要:
The thalamus is the major gate to the cortex and its contribution to cortical receptive field properties is well established. Cortical feedback to the thalamus is, in turn, the anatomically dominant input to relay cells, yet its influence on thalamic processing has been difficult to interpret. For an understanding of complex sensory processing, detailed concepts of the corticothalamic interplay need yet to be established. To study corticogeniculate processing in a model, we draw on various physiological and anatomical data concerning the intrinsic dynamics of geniculate relay neurons, the cortical influence on relay modes, lagged and nonlagged neurons, and the structure of visual cortical receptive fields. In extensive computer simulations we elaborate the novel hypothesis that the visual cortex controls via feedback the temporal response properties of geniculate relay cells in a way that alters the tuning of cortical cells for speed.
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