通过环形成的核小体重新定位
Nucleosome repositioning via loop formation
摘要：
核小体的主动（催化）和被动（内在）重新定位是真核基因转录激活过程中的关键事件。在这里，我们从理论上考虑内在机制，并详细研究DNA环介导的核小体重新定位的能量学和动力学，如Schiessel等人先前提出的（H。作者声明：R. F. Bruinsma和W. M.格尔巴特2001. { \it Phys. Rev. Lett.} 86：4414-4417）。本研究的令人惊讶的结果是在这个模型中核小体运动的固有非局部性-是环机制的直接物理后果。在足够长的DNA模板上，较长的跳跃超过了先前预测的局部运动，这一事实与之前考虑的简单扩散机制形成对比。从所考虑的机制可能产生的实验结果进行预测，讨论和现有的实验结果相比。
英文摘要：
Active (catalysed) and passive (intrinsic) nucleosome repositioning is known to be a crucial event during the transcriptional activation of certain eucaryotic genes. Here we consider theoretically the intrinsic mechanism and study in detail the energetics and dynamics of DNA-loop-mediated nucleosome repositioning, as previously proposed by Schiessel et al. (H. Schiessel, J. Widom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\it Phys. Rev. Lett.} 86:4414-4417). The surprising outcome of the present study is the inherent nonlocality of nucleosome motion within this model -- being a direct physical consequence of the loop mechanism. On long enough DNA templates the longer jumps dominate over the previously predicted local motion, a fact that contrasts simple diffusive mechanisms considered before. The possible experimental outcome resulting from the considered mechanism is predicted, discussed and compared to existing experimental findings.
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