原始分子机器的易位特性及其与遗传密码结构的关系
Translocation Properties of Primitive Molecular Machines and Their Relevance to the Structure of the Genetic Code
摘要：
我们解决的问题，与遗传密码的起源，为什么有三个碱基每个密码子在翻译成蛋白质的过程。作为我们以前的工作的后续行动，我们通过考虑原始分子机器的易位特性来处理这个问题，该机器捕获核糖体/信使RNA相互作用的基本特征，同时在益生元条件下操作。我们的模型由一个短的一维链的带电粒子（rRNA前体）与聚合物（mRNA前体）通过静电力相互作用。链受到外力作用，使其沿着固定在准一维几何形状中的聚合物移动。我们的随机链/聚合物的潜力的统计特性的数值和分析研究表明，在非常一般的条件下，达到的动力学中，链沿聚合物在三个单体的步骤移动。通过调整模型，以考虑当今的遗传序列，我们表明，上述属性增强编码区。基因间序列表现出更接近随机情况的行为。我们认为，这种动力学性质可能是遗传密码的三碱基密码子结构的根本原因之一。
英文摘要：
We address the question, related with the origin of the genetic code, of why are there three bases per codon in the translation to protein process. As a followup to our previous work, we approach this problem by considering the translocation properties of primitive molecular machines, which capture basic features of ribosomal/messenger RNA interactions, while operating under prebiotic conditions. Our model consists of a short one-dimensional chain of charged particles(rRNA antecedent) interacting with a polymer (mRNA antecedent) via electrostatic forces. The chain is subject to external forcing that causes it to move along the polymer which is fixed in a quasi one dimensional geometry. Our numerical and analytic studies of statistical properties of random chain/polymer potentials suggest that, under very general conditions, a dynamics is attained in which the chain moves along the polymer in steps of three monomers. By adjusting the model in order to consider present day genetic sequences, we show that the above property is enhanced for coding regions. Intergenic sequences display a behavior closer to the random situation. We argue that this dynamical property could be one of the underlying causes for the three base codon structure of the genetic code.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
