鸣禽中央听觉区的发放时间和自然声音编码
Spike timing and the coding of naturalistic sounds in a central auditory area of songbirds
摘要：
在自然界中，动物会遇到具有复杂统计和动力学结构的高维感觉刺激。试图研究这些自然信号的神经编码面临的挑战，无论是在选择的信号集成和分析所产生的神经反应。对于斑胸草雀来说，自然主义刺激可以定义为它们在同种鸟类群体中遇到的声音。我们通过记录10-40只斑胸草雀的组来组装这些声音的合奏，然后分析鸣禽中央听觉区（L区）中的单个神经元对连续播放来自该合奏的长片段的反应。根据苍蝇视觉系统中开发的方法，我们测量了尖峰列车提供的关于声刺激的信息，而没有任何假设刺激的哪些特征是相关的。初步结果表明，大量的信息是由尖峰定时携带的，大约有一半的信息只能在时间分辨率优于10毫秒时才能获得;随着时间分辨率提高到2 ms，更多的信息仍在被揭示出来。信息可以被分解为通过将单个尖峰锁定到刺激所携带的信息（或尖峰速率的调制）与由尖峰模式中的定时所携带的。初步结果表明，在字段L，时间模式提供至少~20%的额外信息。因此，单个中枢听觉神经元可以提供自然声音的信息表示，其中尖峰时间可能起着重要作用。
英文摘要：
In nature, animals encounter high dimensional sensory stimuli that have complex statistical and dynamical structure. Attempts to study the neural coding of these natural signals face challenges both in the selection of the signal ensemble and in the analysis of the resulting neural responses. For zebra finches, naturalistic stimuli can be defined as sounds that they encounter in a colony of conspecific birds. We assembled an ensemble of these sounds by recording groups of 10-40 zebra finches, and then analyzed the response of single neurons in the songbird central auditory area (field L) to continuous playback of long segments from this ensemble. Following methods developed in the fly visual system, we measured the information that spike trains provide about the acoustic stimulus without any assumptions about which features of the stimulus are relevant. Preliminary results indicate that large amounts of information are carried by spike timing, with roughly half of the information accessible only at time resolutions better than 10 ms; additional information is still being revealed as time resolution is improved to 2 ms. Information can be decomposed into that carried by the locking of individual spikes to the stimulus (or modulations of spike rate) vs. that carried by timing in spike patterns. Initial results show that in field L, temporal patterns give at least ~20% extra information. Thus, single central auditory neurons can provide an informative representation of naturalistic sounds, in which spike timing may play a significant role.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
