离子通道门控：Kramers型首次通过时间分析
Ion channel gating: a first passage time analysis of the Kramers type
摘要：
电压门控钾离子通道的开放速率表现出特征性的膝状周转，其中常见的指数电压依赖性突然变为线性。这种令人困惑的交叉提出了一个随机的首次通过时间分析的解释。该理论预测，指数电压依赖性与封闭停留时间的指数分布相关。当通道主要关闭时，该特征在大的负电压下发生。与此相反，电压依赖性的线性部分出现在一起的非指数分布的封闭停留时间随着电压的增加，产生一个大的开放率。取决于参数集，封闭时间分布显示出幂律行为，该行为持续了几十年。
英文摘要：
The opening rate of voltage-gated potassium ion channels exhibits a characteristic, knee-like turnover where the common exponential voltage-dependence changes suddenly into a linear one. An explanation of this puzzling crossover is put forward in terms of a stochastic first passage time analysis. The theory predicts that the exponential voltage-dependence correlates with the exponential distribution of closed residence times. This feature occurs at large negative voltages when the channel is predominantly closed. In contrast, the linear part of voltage-dependence emerges together with a non-exponential distribution of closed dwelling times with increasing voltage, yielding a large opening rate. Depending on the parameter set, the closed-time distribution displays a power law behavior which extends over several decades.
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