折叠核的演化守恒
Evolutionary conservation of the folding nucleus
摘要：
在这篇通讯中，我们提出了9种蛋白质的同源序列家族的保守谱的统计分析，这些蛋白质的折叠核是由蛋白质工程方法确定的。我们发现，在所有，但一个蛋白质（AcP）折叠核残基显着比其余的蛋白质更保守。我们的研究有两个方面特别重要：1）根据氨基酸的物理化学性质将其分组; 2）氨基酸概率的适当标准化，反映了进化压力保护某些氨基酸类型本身可能影响蛋白质家族中各种氨基酸类型的浓度。这两个因素中的任何一个都可能使保护概况中的物理和生物"信号“消失。
英文摘要：
In this Communication we present statistical analysis of conservation profiles in families of homologous sequences for nine proteins whose folding nucleus was determined by protein engineering methods. We show that in all but one protein (AcP) folding nucleus residues are significantly more conserved than the rest of the protein. Two aspects of our study are especially important: 1) grouping of amino acids into classes according to their physical-chemical properties and 2) proper normalization of amino acid probabilities that reflects the fact that evolutionary pressure to conserve some amino acid types may itself affect concentration of various amino acid types in protein families. Neglect of any of those two factors may make physical and biological ``signals'' from conservation profiles disappear.
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