转录终止中的平衡分支
Balanced Branching in Transcription Termination
摘要：
基于自由能竞争的随机转录终止理论需要两个或多个反应速率在广泛的物理条件下微妙地平衡。对玻璃和大分子的大量研究表明，在没有新的物质组织原理的情况下，在这样一个大系统中，这是不可能的。我们回顾了终止的实验文献，没有发现这样一个原则的证据，但许多令人不安的不一致，最显着的异常记忆效应。这表明，终止具有确定性的组成部分，可以想象的是，可能根本不是随机的。我们发现，一个关键的实验威尔逊和冯希佩尔据称驳斥确定性终止是一个错误的分析Mg 2+结合的调节作用。
英文摘要：
The theory of stochastic transcription termination based on free-energy competition requires two or more reaction rates to be delicately balanced over a wide range of physical conditions. A large body of work on glasses and large molecules suggests that this should be impossible in such a large system in the absence of a new organizing principle of matter. We review the experimental literature of termination and find no evidence for such a principle but many troubling inconsistencies, most notably anomalous memory effects. These suggest that termination has a deterministic component and may conceivably be not stochastic at all. We find that a key experiment by Wilson and von Hippel allegedly refuting deterministic termination was an incorrectly analyzed regulatory effect of Mg2+ binding.
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