We consider nonparametric estimation of cure-rate based on mixture model under Case-1 interval censoring. We show that the nonparametric maximum-likelihood estimator (NPMLE) of cure-rate is non-unique as well as inconsistent, and propose two estimators based on the NPMLE of the distribution function under this censoring model. We present a cross-validation method for choosing a `cut-off' point needed for the estimators. The limiting distributions of the latter are obtained using extreme-value theory. Graphical illustration of the procedures based on simulated data are provided.
Partially observed cured data occur in the analysis of spontaneous abortion (SAB) in observational studies in pregnancy. In contrast to the traditional cured data, such data has an observable `cured' portion as women who do not abort spontaneously. The data is also subject to left truncate in addition to right-censoring because women may enter or withdraw from a study any time during their pregnancy. Left truncation in particular causes unique bias in the presence of a cured portion. In this paper, we study a cure rate model and develop a conditional nonparametric maximum likelihood approach. …
In this paper, we propose several statistics for testing uniformity under progressive Type-I interval censoring. We obtain the critical points of these statistics and study the power of the proposed tests against a representative set of alternatives via simulation. Finally, we generalize our methods for continuous and completely specified distributions.
We study three estimators for the interval censoring case 2 problem, a histogram-type estimator, proposed in Birgé (1999), the maximum likelihood estimator (MLE) and the smoothed MLE, using a smoothing kernel. Our focus is on the asymptotic distribution of the estimators at a fixed point. The estimators are compared in a simulation study.
In this paper, we mainly discuss the cure model with survival data. Different from the usual survival data with right-censoring, we incorporate the features of left-truncation and measurement error in covariates. Generally speaking, left-truncation causes a biased sample in survival analysis; measurement error in covariates may incur a tremendous bias if we do not deal with it properly. To deal with these challenges, we propose a flexible way to analyze left-truncated survival data and correct measurement error in covariates. The theoretical results are also established in this paper.
Chen and Lio (Computational Statistics and Data Analysis 54: 1581-1591, 2010) proposed five methods for estimating the parameters of generalized exponential distribution under progressive type-I interval censoring scheme. Unfortunately, among them, the proposed EM algorithm is incorrect. Here, we propose the correct EM algorithm and compare its performance with the maximum likelihood estimators and that proposed by Chen and Lio (2010) in a simulation study.
We establish global rates of convergence of the Maximum Likelihood Estimator (MLE) of a multivariate distribution function in the case of (one type of) "interval censored" data. The main finding is that the rate of convergence of the MLE in the Hellinger metric is no worse than $n^{-1/3} (\log n)^γ$ for $γ= (5d - 4)/6$.
An important research topic in survival analysis is related to the modeling and estimation of the cure rate, i.e. the proportion of subjects that will never experience the event of interest. However, most estimation methods proposed so far in the literature do not handle the case of insufficient follow-up, that is when the right end point of the support of the censoring time is strictly less than that of the survival time of the susceptible subjects, and consequently these estimators overestimate the cure rate in that case. We fill this gap by proposing a new estimator of the cure rate that ma…
When analyzing time-to-event data, it often happens that some subjects do not experience the event of interest. Survival models that take this feature into account (called `cure models') have been developed in the presence of covariates. However, the current literature on nonparametric cure models with covariates cannot be applied when the follow-up is insufficient, i.e., when the right endpoint of the support of the censoring time is strictly smaller than that of the survival time of the susceptible subjects. In this paper we attempt to fill this gap in the literature by proposing new estimat…
We study the maximum smoothed likelihood estimator (MSLE) for interval censoring, case 2, in the so-called separated case. Characterizations in terms of convex duality conditions are given and strong consistency is proved. Moreover, we show that, under smoothness conditions on the underlying distributions and using the usual bandwidth choice in density estimation, the local convergence rate is $n^{-2/5}$ and the limit distribution is normal, in contrast with the rate $n^{-1/3}$ of the ordinary maximum likelihood estimator.
Two requirements for pivoting a cumulative distribution function (CDF) in order to construct exact confidence intervals or bounds for a real-valued parameter $θ$ are the monotonicity of this CDF with respect to $θ$ and the existence of solutions of some pertinent equations for $θ$. The second requirement is not fulfilled by the CDF of the maximum likelihood estimator of the exponential scale parameter when the data come from some life-testing scenarios such as type-I censoring, hybrid type-I censoring, and progressive type-I censoring that are subject to time constraints. However, the method h…
Accelerated life-testing (ALT) is a very useful technique for examining the reliability of highly reliable products. It allows testing the products at higher than usual stress conditions to induce failures more quickly and economically than under typical conditions. A special case of ALT are step-stress tests that allow experimenter to increase the stress levels at fixed times. This paper deals with the multiple step step-stress model under the cumulative exposure model with lognormally distributed lifetimes in the presence of Type-II and Progressive Type-II censoring. For this model, the maxi…
In this article, weak convergence of the general non-Markov state transition probability estimator by Titman (2015) is established which, up to now, has not been verified yet for other general non-Markov estimators. A similar theorem is shown for the bootstrap, yielding resampling-based inference methods for statistical functionals. Formulas of the involved covariance functions are presented in detail. Particular applications include the conditional expected length of stay in a specific state, given occupation of another state in the past, as well as the construction of time-simultaneous confi…
This research is motivated by discovering and underpinning genetic causes for the progression of a bilateral eye disease, Age-related Macular Degeneration (AMD), of which the primary outcomes, progression times to late-AMD, are bivariate and interval-censored due to intermittent assessment times. We propose a novel class of copula-based semiparametric transformation models for bivariate data under general interval censoring, which includes the case 1 interval censoring (current status data) and case 2 interval censoring. Specifically, the joint likelihood is modeled through a two-parameter Arc…
Progressive censoring scheme has received considerable attention in recent years. In this paper we introduce a new type-II progressive censoring scheme for two samples. It is observed that the proposed censoring scheme is analytically more tractable than the existing joint progressive type-II censoring scheme proposed by Rasouli and Balakrishnan \cite{RB:2010}. It has some other advantages also. We study the statistical inference of the unknown parameters based on the assumptions that the lifetime distribution of the experimental units for the two samples follow exponential distribution with d…
This work was motivated by observational studies in pregnancy with spontaneous abortion (SAB) as outcome. Clearly some women experience the SAB event but the rest do not. In addition, the data are left truncated due to the way pregnant women are recruited into these studies. For those women who do experience SAB, their exact event times are sometimes unknown. Finally, a small percentage of the women are lost to follow-up during their pregnancy. All these give rise to data that are left truncated, partly interval and right-censored, and with a clearly defined cured portion. We consider the non-…
We propose completely nonparametric methodology to investigate location-scale modelling of two-component mixture cure models, where the responses of interest are only indirectly observable due to the presence of censoring and the presence of so-called long-term survivors that are always censored. We use covariate-localized nonparametric estimators, which depend on a bandwidth sequence, to propose an estimator of the error distribution function that has not been considered before in the literature. When this bandwidth belongs to a certain range of undersmoothing bandwidths, the asymptotic distr…
Fiducial Inference, introduced by Fisher in the 1930s, has a long history, which at times aroused passionate disagreements. However, its application has been largely confined to relatively simple parametric problems. In this paper, we present what might be the first time fiducial inference, as generalized by Hannig et al. (2016), is systematically applied to estimation of a nonparametric survival function under right censoring. We find that the resulting fiducial distribution gives rise to surprisingly good statistical procedures applicable to both one sample and two sample problems. In partic…
In this paper, a competing risks model is analyzed based on improved adaptive type-II progressive censored sample (IAT-II PCS). Two independent competing causes of failures are considered. It is assumed that lifetimes of the competing causes of failure follow exponential distributions with different means. Maximum likelihood estimators (MLEs) for the unknown model parameters are obtained. Using asymptotic normality property of MLE, the asymptotic confidence intervals are constructed. Existence and uniqueness properties of the MLEs are studied. Further, bootstrap confidence intervals are comput…
This paper develops robust confidence intervals in high-dimensional and left-censored regression. Type-I censored regression models are extremely common in practice, where a competing event makes the variable of interest unobservable. However, techniques developed for entirely observed data do not directly apply to the censored observations. In this paper, we develop smoothed estimating equations that augment the de-biasing method, such that the resulting estimator is adaptive to censoring and is more robust to the misspecification of the error distribution. We propose a unified class of robus…
We investigate the performance of model based bootstrap methods for constructing point-wise confidence intervals around the survival function with interval censored data. We show that bootstrapping from the nonparametric maximum likelihood estimator of the survival function is inconsistent for both the current status and case 2 interval censoring models. A model based smoothed bootstrap procedure is proposed and shown to be consistent. In addition, simulation studies are conducted to illustrate the (in)-consistency of the bootstrap methods. Our conclusions in the interval censoring model would…
The progressive Type-II hybrid censoring scheme introduced by Kundu and Joarder (\textit{Computational Statistics and Data Analysis}, 2509-2528, 2006), has received some attention in the last few years. One major drawback of this censoring scheme is that very few observations (even no observation at all) may be observed at the end of the experiment. To overcome this problem, Cho, Sun and Lee (\textit{Statistical Methodology}, 23, 18-34, 2015) recently introduced generalized progressive censoring which ensures to get a pre specified number of failures. In this paper we analyze generalized progr…
We calculate finite sample and asymptotic distributions for the largest censored and uncensored survival times, and some related statistics, from a sample of survival data generated according to an iid censoring model. These statistics are important for assessing whether there is sufficient followup in the sample to be confident of the presence of immune or cured individuals in the population. A key structural result obtained is that, conditional on the value of the largest uncensored survival time, and knowing the number of censored observations exceeding this time, the sample partitions into…
In this paper, we focus on the parametric inference based on the Tampered Random Variable (TRV) model for simple step-stress life testing (SSLT) using Type-II censored data. The baseline lifetime of the experimental units, under normal stress conditions, follows the Gumbel Type-II distribution with $α$ and $λ$ being the shape and scale parameters, respectively. Maximum likelihood estimator (MLE) and Bayes estimator of the model parameters are derived based on Type-II censored samples. We obtain asymptotic intervals of the unknown parameters using the observed Fisher information matrix. Bayes e…
The i.i.d. censoring model for survival analysis assumes two independent sequences of i.i.d. positive random variables, $(T_i^*)_{1\le i\le n}$ and $(U_i)_{1\le i\le n}$. The data consists of observations on the random sequence $\big(T_i=\min(T_i^*,U_i)$ together with accompanying censor indicators. Values of $T_i$ with $T_i^*\le U_i$ are said to be uncensored, those with $T_i^*> U_i$ are censored. We assume that the distributions of the $T_i^*$ and $U_i$ are in the domain of attraction of the Gumbel distribution and obtain the asymptotic distributions, as sample size $n\to\infty$, of the maxi…
The progressive censoring scheme has received considerable amount of attention in the last fifteen years. During the last few years joint progressive censoring scheme has gained some popularity. Recently, the authors Mondal and Kundu ("A new two sample Type-II progressive censoring scheme", arXiv:1609.05805) introduced a balanced two sample Type-II progressive censoring scheme and provided the exact inference when the two populations are exponentially distributed. In this article we consider the case when the two populations follow Weibull distributions with the common shape parameter and diff…
We show that there is an intimate connection between the theory of nonparametric (smoothed) maximum likelihood estimators for certain inverse problems and integral equations. This is illustrated by estimators for interval censoring and deconvolution problems. We also discuss the asymptotic efficiency of the MLE for smooth functionals in these models.
Interval-censored multi-state data arise in many studies of chronic diseases, where the health status of a subject can be characterized by a finite number of disease states and the transition between any two states is only known to occur over a broad time interval. We formulate the effects of potentially time-dependent covariates on multi-state processes through semiparametric proportional intensity models with random effects. We adopt nonparametric maximum likelihood estimation (NPMLE) under general interval censoring and develop a stable expectation-maximization (EM) algorithm. We show that …
We develop asymptotic theory for weighted likelihood estimators (WLE) under two-phase stratified sampling without replacement. We also consider several variants of WLEs involving estimated weights and calibration. A set of empirical process tools are developed including a Glivenko-Cantelli theorem, a theorem for rates of convergence of M-estimators, and a Donsker theorem for the inverse probability weighted empirical processes under two-phase sampling and sampling without replacement at the second phase. Using these general results, we derive asymptotic distributions of the WLE of a finite-dim…
In the context of right-censored and interval-censored data we develop asymptotic formulas to compute pseudo-observations for the survival function and the Restricted Mean Survival Time (RMST). Those formulas are based on the original estimators and do not involve computation of the jackknife estimators. For right-censored data, Von Mises expansions of the Kaplan-Meier estimator are used to derive the pseudo-observations. For interval-censored data, a general class of parametric models for the survival function is studied. An asymptotic representation of the pseudo-observations is derived invo…
Extreme value analysis in the presence of censoring is receiving much attention as it has applications in many disciplines, including survival and reliability studies. Estimation of extreme value index (EVI) is of primary importance as it is a critical parameter needed in estimating extreme events such as quantiles and exceedance probabilities. In this paper, we review several estimators of the extreme value index when data is subject to random censoring. In addition, four estimators are proposed, one based on the exponential regression approximation of log spacings, one based on a Zipf estima…
The purpose of this paper is to construct confidence intervals for the regression coefficients in the Fine-Gray model for competing risks data with random censoring, where the number of covariates can be larger than the sample size. Despite strong motivation from biomedical applications, a high-dimensional Fine-Gray model has attracted relatively little attention among the methodological or theoretical literature. We fill in this gap by developing confidence intervals based on a one-step bias-correction for a regularized estimation. We develop a theoretical framework for the partial likelihood…
The idea of maximizing the likelihood of the observed range for a set of jointly realized counts has been employed in a variety of contexts. The applicability of the MLE introduced in [1] has been extended to the general case of a multivariate sample containing interval censored outcomes. In addition, a kernel density estimator and a related score function have been proposed leading to the construction of a modified Nadaraya-Watson regression estimator. Finally, the author has treated the problems of estimating the parameters of a mutinomial distribution and the analysis of contingency tables …
We consider the problem of estimating the joint distribution function of the event time and a continuous mark variable when the event time is subject to interval censoring case 1 and the continuous mark variable is only observed in case the event occurred before the time of inspection. The nonparametric maximum likelihood estimator in this model is known to be inconsistent. We study two alternative smooth estimators, based on the explicit (inverse) expression of the distribution function of interest in terms of the density of the observable vector. We derive the pointwise asymptotic distributi…
A Hybrid censoring scheme is mixture of Type-I and Type-II censoring schemes. Based on hybrid censored samples, this paper deals with the in- ference on R = P(X > Y ), when X and Y are two independent Weibull distributions with different scale parameters, but having the same shape pa- rameter. The maximum likelihood estimator (MLE), and the approximate MLE (AMLE) of R are obtained. The asymptotic distribution of the maxi- mum likelihood estimator of R is obtained. Based on the asymptotic distribu- tion, the confidence interval of R can be derived. Two bootstrap confidence intervals are also pr…
We consider projection methods for the estimation of the cumulative distribution function under interval censoring, case 1. Such censored data also known as current status data, arise when the only information available on the variable of interest is whether it is greater or less than an observed random time. Two types of adaptive estimators are investigated. The first one is a two-step estimator built as a quotient estimator. The second estimator results from a mean square regression contrast. Both estimators are proved to achieve automatically the standard optimal rate associated with the un…
For the univariate current status and, more generally, the interval censoring model, distribution theory has been developed for the maximum likelihood estimator (MLE) and smoothed maximum likelihood estimator (SMLE) of the unknown distribution function, see, e.g., [12], [7], [4], [5], [6], [10], [11] and [8]. For the bivariate current status and interval censoring models distribution theory of this type is still absent and even the rate at which we can expect reasonable estimators to converge is unknown. We define a purely discrete plug-in estimator of the distribution function which locally c…
In this paper we consider the statistical inference of the unknown parameter of an exponential distribution based on the time truncated data. The time truncated data occurs quite often in the reliability analysis for type-I or hybrid censoring cases. All the results available today are based on the conditional argument that at least one failure occurs during the experiment. In this paper we provide some inferential results based on the unconditional argument. We extend the results for some two-parameter distributions also.
In this article, we consider the estimation of unknown parameters of Weibull distribution when the lifetime data are observed in the presence of progressively type-I hybrid censoring scheme. The Newton-Raphson algorithm, Expectation-Maximization (EM) algorithm and Stochastic EM (SEM) algorithm are utilized to derive the maximum likelihood estimates (MLEs) for the unknown parameters. Moreover, Bayesian estimators using Tierney-Kadane Method and Markov Chain Monte Carlo (MCMC) method are obtained under three different loss functions, namely, squared error loss (SEL), linear-exponential (LINEX) a…
We consider the problem of estimating the distribution of time-to-event data that are subject to censoring and for which the event of interest might never occur, i.e., some subjects are cured. To model this kind of data in the presence of covariates, one of the leading semiparametric models is the promotion time cure model \citep{yakovlev1996}, which adapts the Cox model to the presence of cured subjects. Estimating the conditional distribution results in a complicated constrained optimization problem, and inference is difficult as no closed-formula for the variance is available. We propose a …
