质谱蛋白质组学诊断：制定验证范式
Mass spectrometry proteomic diagnosis: enacting the validation paradigm
摘要：
本文提出了一种方法来评估和验证质谱数据的建设一个“早期预警”的诊断程序。我们描述了一个设计的实验的实施，并强调一致和正确使用的验证为基础的评价-这是一个关键的要求，以实现无偏评估的能力，质谱数据诊断在这种情况下。然而，严格遵守验证作为一项科学原则通常意味着分析师必须做出选择。就像统计分析中的所有选择一样，验证是有代价的！我们提出了一个详细和广泛的讨论所涉及的问题，并提出更大的重视和要求验证将进入临床蛋白质组学。
英文摘要：
This paper presents an approach to the evaluation and validation of mass spectrometry data for construction of an `early warning' diagnostic procedure. We describe implementation of a designed experiment and place emphasis on the consistent and correct use of validation based evaluation - which is a key requirement to achieve unbiased assessment of the ability of mass spectrometry data for diagnosis in this setting. Strict adherence to validation as a scientific principle will however typically imply that the analyst must make choices. Like all choices in statistical analysis, validation comes at a cost! We present a detailed and extensive discussion of the issues involved and propose that much greater emphasis and requirement for validation would enter clinical proteomic science.
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