In this chapter we describe new neural-network techniques developed for visual mining clinical electroencephalograms (EEGs), the weak electrical potentials invoked by brain activity. These techniques exploit fruitful ideas of Group Method of Data Handling (GMDH). Section 2 briefly describes the standard neural-network techniques which are able to learn well-suited classification modes from data presented by relevant features. Section 3 introduces an evolving cascade neural network technique which adds new input nodes as well as new neurons to the network while the training error decreases. This algorithm is applied to recognize artifacts in the clinical EEGs. Section 4 presents the GMDH-type polynomial networks learnt from data. We applied this technique to distinguish the EEGs recorded from an Alzheimer and a healthy patient as well as recognize EEG artifacts. Section 5 describes the new neural-network technique developed to induce multi-class concepts from data. We used this technique for inducing a 16-class concept from the large-scale clinical EEG data. Finally we discuss perspectives of applying the neural-network techniques to clinical EEGs.
A new technique is presented developed to learn multi-class concepts from clinical electroencephalograms. A desired concept is represented as a neuronal computational model consisting of the input, hidden, and output neurons. In this model the hidden neurons learn independently to classify the electroencephalogram segments presented by spectral and statistical features. This technique has been applied to the electroencephalogram data recorded from 65 sleeping healthy newborns in order to learn a brain maturation concept of newborns aged between 35 and 51 weeks. The 39399 and 19670 segments fro…
We describe a polynomial network technique developed for learning to classify clinical electroencephalograms (EEGs) presented by noisy features. Using an evolutionary strategy implemented within Group Method of Data Handling, we learn classification models which are comprehensively described by sets of short-term polynomials. The polynomial models were learnt to classify the EEGs recorded from Alzheimer and healthy patients and recognize the EEG artifacts. Comparing the performances of our technique and some machine learning methods we conclude that our technique can learn well-suited polynomi…
In this paper we describe a new method combining the polynomial neural network and decision tree techniques in order to derive comprehensible classification rules from clinical electroencephalograms (EEGs) recorded from sleeping newborns. These EEGs are heavily corrupted by cardiac, eye movement, muscle and noise artifacts and as a consequence some EEG features are irrelevant to classification problems. Combining the polynomial network and decision tree techniques, we discover comprehensible classification rules whilst also attempting to keep their classification error down. This technique is …
A new learning algorithm for Evolving Cascade Neural Networks (ECNNs) is described. An ECNN starts to learn with one input node and then adding new inputs as well as new hidden neurons evolves it. The trained ECNN has a nearly minimal number of input and hidden neurons as well as connections. The algorithm was successfully applied to classify artifacts and normal segments in clinical electroencephalograms (EEGs). The EEG segments were visually labeled by EEG-viewer. The trained ECNN has correctly classified 96.69% of the testing segments. It is slightly better than a standard fully connected n…
Recent advances in deep learning have led to the development of models approaching the human level of accuracy. However, healthcare remains an area lacking in widespread adoption. The safety-critical nature of healthcare results in a natural reticence to put these black-box deep learning models into practice. This paper explores interpretable methods for a clinical decision support system called sleep staging, an essential step in diagnosing sleep disorders. Clinical sleep staging is an arduous process requiring manual annotation for each 30s of sleep using physiological signals such as electr…
A neural network based technique is presented, which is able to successfully extract polynomial classification rules from labeled electroencephalogram (EEG) signals. To represent the classification rules in an analytical form, we use the polynomial neural networks trained by a modified Group Method of Data Handling (GMDH). The classification rules were extracted from clinical EEG data that were recorded from an Alzheimer patient and the sudden death risk patients. The third data is EEG recordings that include the normal and artifact segments. These EEG data were visually identified by medical …
Objective: Causality mining is an active research area, which requires the application of state-of-the-art natural language processing techniques. In the healthcare domain, medical experts create clinical text to overcome the limitation of well-defined and schema driven information systems. The objective of this research work is to create a framework, which can convert clinical text into causal knowledge. Methods: A practical approach based on term expansion, phrase generation, BERT based phrase embedding and semantic matching, semantic enrichment, expert verification, and model evolution has …
We used redescription mining to find interpretable rules revealing associations between those determinants that provide insights about the Alzheimer's disease (AD). We extended the CLUS-RM redescription mining algorithm to a constraint-based redescription mining (CBRM) setting, which enables several modes of targeted exploration of specific, user-constrained associations. Redescription mining enabled finding specific constructs of clinical and biological attributes that describe many groups of subjects of different size, homogeneity and levels of cognitive impairment. We confirmed some previou…
tSPM+; a high-performance algorithm for mining transitive sequential patterns from clinical data
Massachusetts General Hospital（麻省总医院）；University Medical Center Göttingen（哥廷根大学医学中心）；Georg-August-Universität Göttingen（哥廷根大学）；Harvard Medical School（哈佛医学院）；Mass General Brigham（麻省总医院布里格姆医疗系统）
本文提出高性能 tSPM+ 算法，通过在时间模式中增加持续时间维度优化 tSPM，实现最高 980 倍加速与 48 倍内存优化，并提供 Docker 容器与 R 包以集成至机器学习工作流，成功应用于识别 Post COVID-19 患者。
The CDOI outcome measure - a patient-reported outcome (PRO) instrument utilizing direct client feedback - was implemented in a large, real-world behavioral healthcare setting in order to evaluate previous findings from smaller controlled studies. PROs provide an alternative window into treatment effectiveness based on client perception and facilitate detection of problems/symptoms for which there is no discernible measure (e.g. pain). The principal focus of the study was to evaluate the utility of the CDOI for predictive modeling of outcomes in a live clinical setting. Implementation factors w…
Université Sorbonne Paris Nord（索邦巴黎西岱大学）；Sorbonne Université（索邦大学）；INSERM（法国国家健康与医学研究院）；Laboratoire de Recherche en Informatique, CNRS/Université Paris-Sud/Université Paris-Saclay（计算机研究实验室，法国国家科学研究中心/巴黎南大学/巴黎萨克雷大学）
Clinical trials are the basis of Evidence-Based Medicine. Trial results are reviewed by experts and consensus panels for producing meta-analyses and clinical practice guidelines. However, reviewing these results is a long and tedious task, hence the meta-analyses and guidelines are not updated each time a new trial is published. Moreover, the independence of experts may be difficult to appraise. On the contrary, in many other domains, including medical risk analysis, the advent of data science, big data and visual analytics allowed moving from expert-based to fact-based knowledge. Since 12 yea…
RDMA: Cost Effective Agent-Driven Rare Disease Mining from Electronic Health Records
Department of Computer Science, University of Illinois Urbana-Champaign（伊利诺伊大学厄巴纳-香槟分校计算机科学系）；Department of Pediatrics, University of Illinois College of Medicine Peoria（伊利诺伊大学皮奥里亚医学院儿科系）
University of Trier（特里尔大学）；German Research Center for Artificial Intelligence (DFKI)（德国人工智能研究中心（DFKI））；University Hospital Münster（明斯特大学医院）；Heinrich Heine University（海因里希·海涅大学）
Conformance checking is a process mining technique that allows verifying the conformance of process instances to a given model. Thus, this technique is predestined to be used in the medical context for the comparison of treatment cases with clinical guidelines. However, medical processes are highly variable, highly dynamic, and complex. This makes the use of imperative conformance checking approaches in the medical domain difficult. Studies show that declarative approaches can better address these characteristics. However, none of the approaches has yet gained practical acceptance. Another cha…
The surging amount of biomedical literature & digital clinical records presents a growing need for text mining techniques that can not only identify but also semantically relate entities in unstructured data. In this paper we propose a text mining framework comprising of Named Entity Recognition (NER) and Relation Extraction (RE) models, which expands on previous work in three main ways. First, we introduce two new RE model architectures -- an accuracy-optimized one based on BioBERT and a speed-optimized one utilizing crafted features over a Fully Connected Neural Network (FCNN). Second, we ev…
Mining Social Determinants of Health for Heart Failure Patient 30-Day Readmission via Large Language Model
Department of Computer Science, Emory University（计算机科学系，埃默里大学）；Nell Hodgson Woodruff School of Nursing, Emory University（Nell Hodgson Woodruff护理学院，埃默里大学）
DF-DM: A foundational process model for multimodal data fusion in the artificial intelligence era
Massachusetts Institute of Technology（麻省理工学院）；Universidad del Cauca（考卡大学）；University of Michigan（密歇根大学）；Universidad de Chile（智利大学）；São Paulo Federal University（圣保罗联邦大学）；Harvard TH Chan School of Public Health（哈佛陈曾熙公共卫生学院）；Beth Israel Deaconess Medical Center（贝斯以色列女执事医疗中心）
University of California Los Angeles（加利福尼亚大学洛杉矶分校）
With the recent availability of Electronic Health Records (EHR) and great opportunities they offer for advancing medical informatics, there has been growing interest in mining EHR for improving quality of care. Disease diagnosis due to its sensitive nature, huge costs of error, and complexity has become an increasingly important focus of research in past years. Existing studies model EHR by capturing co-occurrence of clinical events to learn their latent embeddings. However, relations among clinical events carry various semantics and contribute differently to disease diagnosis which gives prec…
Laboratório Nacional de Computação Científica（国家科学计算实验室）；Centro Paula Souza（保拉·苏扎中心）；Universidade Federal de Juiz de Fora（茹伊斯迪福拉联邦大学）
The sequence of visits and procedures performed by the patient in the health system, also known as the patient's pathway or trajectory, can reveal important information about the clinical treatment adopted and the health service provided. The rise of electronic health data availability made it possible to assess the pathways of a large number of patients. Nevertheless, some challenges also arose concerning how to synthesize these pathways and how to mine them from the data, fostering a new field of research. The objective of this review is to survey this new field of research, highlighting rep…
Potential of Multimodal Large Language Models for Data Mining of Medical Images and Free-text Reports
Institute of Medical Research, Northwestern Polytechnical University（西北工业大学医学研究院）；School of Computing, University of Georgia（佐治亚大学计算学院）；School of Life Science and Technology, University of Electronic Science and Technology of China（电子科技大学生命科学与技术学院）；School of Automation, Northwestern Polytechnical University（西北工业大学自动化学院）；School of Electronics and Information, Northwestern Polytechnical University（西北工业大学电子信息学院）；School of Biomedical Engineering, ShanghaiTech University（上海科技大学生物医学工程学院）；Lingang Laboratory（临港实验室）
