信号转导建模的计算技术集成
Integration of Computational Techniques for the Modelling of Signal Transduction
摘要：
一个细胞可以被看作是一个自适应的自主智能体或一个自适应自主智能体的社会，其中每个智能体都可以根据其认知能力表现出特定的行为。我们提出了一个细胞内信号模型，通过整合几种计算技术到一个代理为基础的范例。Cellulat模型考虑了细胞内信号网络的两个基本方面：认知能力和空间组织。举例说明系统的功能，通过模拟EGFR信号通路，我们讨论的方法以及目的的细胞内信号虚拟实验室，目前正在开发中。
英文摘要：
A cell can be seen as an adaptive autonomous agent or as a society of adaptive autonomous agents, where each can exhibit a particular behaviour depending on its cognitive capabilities. We present an intracellular signalling model obtained by integrating several computational techniques into an agent-based paradigm. Cellulat, the model, takes into account two essential aspects of the intracellular signalling networks: cognitive capacities and a spatial organization. Exemplifying the functionality of the system by modelling the EGFR signalling pathway, we discuss the methodology as well as the purposes of an intracellular signalling virtual laboratory, presently under development.
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