发表机构
Faculty of Sciences, Universidad Autónoma del Estado de México; Centro de Microcirugía Ocular（墨西哥自治州大学理学院; 眼显微外科中心）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本研究提出G-EXO，一种逆设计的各向异性角膜基质内支架，通过有限元模型优化几何与刚度，减少圆锥角膜的彗差约5%，为光学-生物力学逆设计提供计算可行性框架。
AI 中文摘要
我们提出G-EXO，一种用于圆锥角膜的逆设计角膜基质内支架。与传统的角膜环植入术不同，G-EXO被构想为一种患者可定制、扇形且各向异性的支架，其几何形状和刚度经过优化，以重新分布角膜变形并减少不对称光学像差。我们开发了一个三维有限元筛选模型，包含局部扩张性薄弱、生理性眼内压和基质内加固区域。一个代表性设计在压力诱导的彗差方面产生了适度但一致的减少，网格细化估计约为5%，而位移和应力指标在数值上更为稳定。该研究被呈现为计算可行性框架而非临床验证。其主要贡献是将基质内加固表述为一个自由形式的光学-生物力学逆设计问题。患者特异性断层扫描、非线性各向异性角膜力学、完整光学建模和离体验证被确定为下一步工作。
英文摘要
We propose G-EXO, an inverse-designed intrastromal corneal exoskeleton for keratoconus. Unlike conventional intracorneal ring approaches, G-EXO is conceived as a patient-customizable, sectorial and anisotropic scaffold whose geometry and stiffness are optimized to redistribute corneal deformation and reduce asymmetric optical aberrations. We develop a three-dimensional finite-element screening model with localized ectatic weakening, physiological intraocular pressure, and an intrastromal reinforcement domain. A representative design produced a modest but consistent reduction in pressure-induced coma, with a mesh-refined estimate of about 5%, while displacement and stress metrics were more numerically stable. The study is presented as a computational feasibility framework rather than a clinical validation. Its main contribution is to formulate intrastromal reinforcement as a free-form optical-biomechanical inverse-design problem. Patient-specific tomography, nonlinear anisotropic corneal mechanics, full optical modeling, and ex-vivo validation are identified as the next steps.
