IMPPAT 3.0：印度药用植物植物化学物质与配方的更新FAIR数据库
IMPPAT 3.0: An updated FAIR database of phytochemicals and formulations of Indian Medicinal plants
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中文总结 AI 辅助
IMPPAT 3.0更新了印度药用植物数据库，整合阿育吠陀配方并构建知识图谱，通过网络医学分析验证了其在药物发现中的实用价值。
中文摘要 AI 辅助
阿育吠陀配方代表了传统知识的丰富来源，涵盖了独特的治疗方法、药用成分和药物作用的基本原理。然而，将这些知识与标准化的现代生物医学术语和资源进行系统性整合仍然有限。在此，我们介绍IMPPAT 3.0，这是印度药用植物、植物化学与治疗学（IMPPAT：此https URL）数据库的更新版本，其通过纳入来自权威来源的经过整理和协调的阿育吠陀配方信息来扩展其范围，同时扩大其对药用植物、植物化学物质和治疗用途术语的覆盖。IMPPAT 3.0进一步丰富了植物和植物化学信息，增加了临床试验、专利、生物活性、蛋白质靶点、光谱数据、植物图像链接和AyuCaRe报告的注释。编译的数据还组织为IMPPAT-KG，这是一个知识图谱，能够探索IMPPAT实体之间的关系。我们通过针对类风湿关节炎（RA）报道的单草药药物（SHDs）的网络医学分析展示了该资源的实用性，揭示了其蛋白质靶点与RA相关基因的显著接近性，并指出了对RA发病机制可能具有互补作用的植物化学对。总之，通过整合传统医学知识，IMPPAT为系统研究印度药用植物和阿育吠陀配方用于药物发现应用提供了一个符合FAIR原则的民族药理学平台。
英文摘要
Ayurvedic formulations represent a rich source of traditional knowledge, encompassing distinct therapeutic approaches, medicinal ingredients, and underlying principles of drug action. However, systematic integration of this knowledge with standardized modern biomedical terminology and resources remains limited. Here, we present IMPPAT 3.0, an updated version of the Indian Medicinal Plants, Phytochemistry And Therapeutics (IMPPAT: https://cb.imsc.res.in/imppat/) database that extends its scope by incorporating curated and harmonized information on Ayurvedic formulations from authoritative sources, while expanding its coverage of medicinal plants, phytochemicals, and therapeutic use terms. IMPPAT 3.0 further enriches plant and phytochemical information with annotations on clinical trials, patents, bioactivity, protein targets, spectral data, plant image links, and AyuCaRe reports. The compiled data is also organized as IMPPAT-KG, a knowledge graph that enables exploration of relationships among IMPPAT entities. We demonstrate the utility of the resource through a network medicine analysis of single herbal drugs (SHDs) reported for rheumatoid arthritis (RA), revealing significant proximity of their protein targets to RA-associated genes, and pinpointing of phytochemical pairs with potentially complementary effects on RA pathogenesis. In conclusion, by integrating traditional medicinal knowledge, IMPPAT provides a FAIR-compliant ethnopharmacological platform for systematic investigation of Indian medicinal plants and Ayurvedic formulations for drug discovery applications.
发表机构
- The Institute of Mathematical Sciences (IMSc)（数学科学研究所）
- Homi Bhabha National Institute (HBNI)（霍米·巴巴国立学院）
机构由 AI 辅助整理，请以论文原文为准。
