发表机构
Vrije Universiteit Amsterdam; Bielefeld University（阿姆斯特丹自由大学; 比勒费尔德大学）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
提出一种马赫-曾德尔配置的倾斜照明全场傅里叶域OCT系统，通过超定系统闭式解实现数字共聚焦重建，提升空间带宽积利用和分辨率，结合两类OCT优势。
AI 中文摘要
全场傅里叶域光学相干断层扫描（FF-FD-OCT）能够实现快速体积成像，但缺乏点扫描OCT固有的共聚焦门控。通过在多角度倾斜照明下采集体积数据，可以在后处理中合成数字共聚焦体积，这一技术最初在反射矩阵成像（RMI）框架内开发。然而，现有实现通常采用时域、离轴或迈克尔逊干涉仪配置，这降低了灵敏度、速度和可用的空间带宽积（SBP）。在此，我们提出了一种马赫-曾德尔配置的倾斜照明FF-FD-OCT系统。该设置能够最优利用SBP，使有效采集吞吐量提高至四倍。此外，我们将散射和像差视为一个超定系统，从而允许交替最小二乘问题的闭式解。所得到的迭代优化等效于最先进的单次散射闭环累积（CLASS）算法。我们在透镜组织、PSF体模、USAF靶标和模型眼中演示了该设置和重建方法。所得到的数字共聚焦体积提供了局部优化的聚焦和检测质量，并且与传统FF-FD-OCT相比，显示出改进的分辨率和信噪比（SNR）。该技术结合了FF-FD-OCT和共聚焦OCT的优势，同时减轻了两种方法的局限性。
英文摘要
Full-field Fourier-domain optical coherence tomography (FF-FD-OCT) enables rapid volumetric imaging but lacks the confocal gating inherent to point-scanning OCT. By acquiring volumes under multiple oblique illuminations, a digital confocal volume can be synthesized in post-processing, a technique originally developed within the framework of reflection matrix imaging (RMI). Existing implementations, however, are often time-domain, off-axis, or use a Michelson interferometer, which reduces sensitivity, speed and the usable space-bandwidth product (SBP). Here, we present an oblique-illumination FF-FD-OCT system in a Mach-Zehnder configuration. This setup enables optimal use of SBP, providing up to a fourfold increase in effective acquisition throughput. In addition, we pose the scattering and aberrations as an overdetermined system, allowing a closed-form solution of an alternating least squares problem. The resulting iterative optimization is equivalent to the state-of-the-art closed-loop accumulation of single scattering (CLASS) algorithm. We demonstrate the setup and reconstruction method in lens tissue, a PSF phantom, a USAF target, and a model eye. The resulting digital confocal volumes provide locally optimized focusing and detection quality, and show improved resolution and signal-to-noise ratio (SNR) compared to conventional FF-FD-OCT. The technique combines the advantages of FF-FD-OCT and confocal OCT while mitigating the limitations of both approaches.
Comments17 pages, 7 figures
