发表机构
University College London; University of Glasgow（伦敦大学学院; 格拉斯哥大学）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本文介绍FSM V2，一种多波长可穿戴NIRS设备，通过双光源和三光电二极管配置监测胎盘氧合与代谢，经体模和临床验证，为床旁胎盘健康监测提供新方案。
AI 中文摘要
我们在此介绍FetalSenseM V2（FSM V2），一种基于六个近红外波长（782、800、818、830、848和888 nm）LED照明的无线、可穿戴、多波长近红外光谱（NIRS）设备。它利用位于传感器主体柔性翼上的两个光源，以及对称放置在中心、彼此相距1 cm的三个光电二极管。该配置提供了两组三个源-探测器距离（SDS），分别为3、4和5 cm。FSM V2能够估计胎盘中HbO2、HHb和oxCCO浓度的动态相对变化。同时，双组SDS还使得能够使用多距离算法，如空间分辨光谱（SRS）和双斜率（DS），来估计胎盘氧饱和度（PlO2）。FSM V2是新一代可穿戴NIRS设备的首个实例，为床旁胎盘健康的智能和先进监测铺平了道路。FSM V2在基于光学体模的台架计量平台上，以及针对金标准时域（TD）NIRS系统进行了成功验证，随后在伦敦大学学院医院（UCLH）进行的妊娠监测试验中进行了初步临床应用和可用性示例，作为体内概念验证研究的一部分。
英文摘要
We present here the FetalSenseM V2 (FSM V2), a wireless and wearable, multi-wavelength, NIRS device, based on LED illumination at six NIR wavelengths (782, 800, 818, 830, 848 and 888 nm). It utilises two sources located on the flexible wings of the sensor body, and three photodiodes placed symmetrically in its centre at 1 cm from each other. The configuration provides two sets of three source-to-detector distances (SDS) at 3, 4 and 5 cm. FSM V2 allows estimation of dynamic, relative changes in placental concentrations of HbO2, HHb and oxCCO. At the same time, the dual set of SDS also enables the use of multi-distance algorithms, such as spatially-resolved spectroscopy (SRS) and Dual Slope (DS), for estimating placental oxygen saturation (PlO2). FSM V2 is the first example of a new generation of wearable NIRS devices, paving the way for smart and advanced monitoring of placental health at bedside. The FSM V2 was successfully validated on a bench-testing, metrological platform based on optical phantoms, as well as against a gold-standard, time-domain (TD) NIRS system, before moving to preliminary examples of clinical application and usability on pregnancy monitoring trials at University College Lon-don Hospital (UCLH), conducted as part of an in vivo proof-of-concept study.
