发表机构
Koç University（博阿齐奇大学）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本文提出一种受活细胞受体适应启发的分子通信接收机，通过细胞内抗逆积分反馈网络自主调谐解离常数至几何平均值，最小化比特错误概率，显著优于非自适应接收机。
AI 中文摘要
分子通信（MC）利用分子作为信息载体，在工程细胞和人造设备之间进行通信，应用于生物纳米物联网。MC接收机通常采用配体受体，其对二进制信号中两个接收浓度水平的区分取决于受体相对于解离常数的位置。发射机-接收机距离的变化、配体降解和干扰可使两个水平均偏移至固定受体的动态范围之外，从而损害检测性能。先前的工作通过将解离常数外部调谐至估计接收水平的几何平均值来恢复性能。本文受活细胞中受体适应的启发，研究了一种接收机，其细胞内抗逆积分反馈网络感知受体占用率，并通过调节分子自主调谐解离常数。对于恒定的接收水平和等概率比特，我们证明，在不知道这些水平的情况下，该网络在平衡时将解离常数设定为其几何平均值，该值在任意固定受体协同性下最小化比特错误概率（BEP）。我们推导了该反馈环路的增益、带宽、噪声和稳定性边界。网络平均的随机比特引入自噪声，该噪声设定了一个独立于网络分子数量的错误底限，并与信道跟踪误差相平衡，产生环路速度设计规则。对于接收水平在24个环路时间常数的相干时间内变化五倍的情况，与最佳非自适应接收机相比，自适应对非协同受体将BEP降低61倍，对协同受体降低410倍。该收益随相干时间增加而增长，并在中等变化深度时达到峰值。
英文摘要
Molecular communication (MC) uses molecules as information carriers among engineered cells and artificial devices in the Internet of Bio-Nano Things. MC receivers commonly employ ligand receptors, whose discrimination between the two received concentration levels of binary signaling depends on their position relative to the dissociation constant. Changes in the transmitter-receiver distance, ligand degradation, and interference can shift both levels below or above the dynamic range of fixed receptors, impairing detection. Previous work restored performance by externally tuning the dissociation constant to the geometric mean of the estimated received levels. In this paper, inspired by receptor adaptation in living cells, we investigate a receiver whose intracellular antithetic integral feedback network senses the receptor occupancy and autonomously tunes the dissociation constant through a modulator molecule. For constant received levels and equiprobable bits, we prove that, without knowing these levels, the network sets the dissociation constant at equilibrium to their geometric mean, which minimizes the bit error probability (BEP) for any fixed receptor cooperativity. We derive the gain, bandwidth, noise, and stability boundary of this feedback loop. The random bits averaged by the network induce self-noise, which sets an error floor independent of the network molecule count and, balanced against the channel-tracking error, yields a loop-speed design rule. For received levels varying fivefold over a coherence time of 24 loop time constants, adaptation reduces the BEP 61-fold for non-cooperative and 410-fold for cooperative receptors, compared with the best non-adaptive receiver. This benefit grows with the coherence time and peaks at moderate variation depths.
