发表机构
University of São Paulo; IMT School for Advanced Studies（圣保罗大学; 高等研究学院）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本研究通过数值模拟揭示，呼吸簇同步在热敏感、电场和噪声等现实条件下仍稳健存在，其核心机制由网络对称性与星形胶质细胞反馈的相互作用主导，为理解胶质调节皮层状态切换提供了定量框架。
AI 中文摘要
星形胶质细胞日益被认为是神经动力学的活跃调节者，但它们在大规模同步中的作用仍未完全理解。基于神经元-星形胶质细胞网络中呼吸簇同步的发现，我们通过纳入热敏感神经元动力学、内在电场相互作用、随机扰动和延迟的星形胶质细胞反馈，研究了这种现象在更生物现实条件下是否持续存在。通过对包含结构对称神经元子集的网络进行系统数值模拟，我们表明以同步和去同步状态间歇交替为特征的呼吸簇在广泛的生物物理条件下保持稳健。结果揭示了星形胶质细胞衰减和反馈参数的非单调依赖性，中间值通过缓慢的推拉调节机制最大化节律性切换。温度和电场效应主要调节神经元兴奋性和呼吸状态对噪声的耐受性，而升高的随机扰动逐渐破坏簇相干性。相反，该现象对生物现实的星形胶质细胞延迟表现出显著稳健性。重要的是，我们的发现表明呼吸同步的出现根本上由网络对称性和星形胶质细胞介导的反馈之间的相互作用控制，而温度、电场和噪声作为其稳定性和时间组织的调节器。这些结果确立了呼吸簇同步作为星形胶质细胞调节网络的稳健组织原则，并提供了定量框架，用于理解胶质调节如何在现实生理条件下塑造皮层状态切换。
英文摘要
Astrocytes are increasingly recognized as active regulators of neural dynamics, yet their role in large-scale synchronization remains incompletely understood. Building on the discovery of breathing cluster synchronization in neuron-astrocyte networks, we investigate whether this phenomenon persists under more biologically realistic conditions by incorporating thermosensitive neuronal dynamics, intrinsic electric-field interactions, stochastic perturbations, and delayed astrocytic feedback. Through systematic numerical simulations of a network containing structurally symmetric neuronal subsets, we show that breathing clusters characterized by intermittent alternations between synchronized and desynchronized states, remain robust across a broad range of biophysical conditions. The results reveal a non-monotonic dependence on astrocytic attenuation and feedback parameters, with intermediate values maximizing rhythmic switching through a slow push-pull regulatory mechanism. Temperature and electric-field effects primarily modulate neuronal excitability and the tolerance of the breathing state to noise, while elevated stochastic perturbations progressively destabilize cluster coherence. In contrast, the phenomenon exhibits remarkable robustness to biologically realistic astrocytic delays. Importantly, our findings indicate that the emergence of breathing synchronization remains fundamentally governed by the interplay between network symmetry and astrocyte-mediated feedback, whereas temperature, electric fields, and noise act as modulators of its stability and temporal organization. These results establish breathing cluster synchronization as a robust organizing principle of astrocyte-regulated networks and provide a quantitative framework for understanding how glial regulation shapes cortical state-switching under realistic physiological conditions.
