发表机构
NYU Langone Health; NYU Tandon School of Engineering; Kessler Foundation（纽约大学朗格尼健康中心; 纽约大学坦登工程学院; 凯斯勒基金会）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本研究通过同步眼动、手部追踪和物体检测的多模态方法，发现多发性硬化症患者在九孔柱测试中的减慢主要发生在精确操作和过渡阶段，揭示了完成时间无法反映的眼手协调缺陷。
AI 中文摘要
多发性硬化症（MS）可通过运动、感觉、认知和视觉缺陷损害上肢功能。尽管九孔柱测试（9-HPT）被广泛用于评估手部灵活性，但仅凭完成时间对表现背后的眼手协调性提供的洞察有限。我们通过同步眼动追踪、无标记手部追踪和物体检测，对九名多发性硬化症患者（PwMS）和九名健康对照者的9-HPT表现进行了表征。每个插柱周期被分为运输、操作与插入以及返回料盒三个阶段。PwMS的总体完成时间更长。非惯用手的运输阶段延长，惯用手的操作阶段延长，而双手的返回料盒阶段持续时间均更长，且该阶段差异最大。PwMS在惯用手操作时每次插柱还多出约一次注视，且注视落点位置的变异性更大。扫视幅度和平均放置误差在两组间无显著差异，且两组中注视通常先于手部运动。这些探索性发现表明，MS相关的减慢集中在需要精确操作和过渡到下一个插柱的阶段。对9-HPT的多模态评估可以揭示仅凭完成时间无法捕捉的协调缺陷。
英文摘要
Multiple sclerosis (MS) can impair upper-extremity function through motor, sensory, cognitive, and visual deficits. Although the Nine-Hole Peg Test (9-HPT) is widely used to assess dexterity, completion time alone provides limited insight into the eye-hand coordination underlying performance. We characterized 9-HPT performance in nine people with MS (PwMS) and nine healthy controls using simultaneous eye tracking, markerless hand tracking, and object detection. Each peg cycle was divided into transport, manipulation and insertion, and return-to-bin phases. PwMS had longer overall completion times. Transport was prolonged with the non-dominant hand, manipulation was prolonged with the dominant hand, and return-to-bin duration was longer with both hands, representing the largest phase difference. PwMS also made approximately one additional fixation per peg and showed greater variability in gaze landing position during dominant-hand performance. Saccadic amplitude and mean placement error did not differ significantly between groups, and gaze generally preceded hand movement in both groups. These exploratory findings suggest that MS-related slowing is concentrated in phases requiring precise manipulation and transition to the next peg. Multimodal assessment of the 9-HPT can reveal coordination deficits not captured by completion time alone.
Comments10 pages, 9 Figures
