发表机构
Bangladesh University of Engineering and Technology（孟加拉国工程与技术大学）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本研究利用QSM衍生生物标志物（MHR和OEFHR）定量评估健康与AD大脑的半球不对称性，发现微小但具前景的差异，提示结构不对称性可作为AD神经退行性变的潜在标志物。
AI 中文摘要
研究大脑偏侧化及由此产生的半球不对称性一直是许多研究者关注的话题。然而，很少有研究关注与神经退行性变相关的大脑偏侧化和半球不对称性的差异。此外，定量磁化率成像（QSM）尚未被广泛用于探究这些差异。本文旨在通过计算两个半球之间的髓鞘半球比率（MHR）和氧摄取分数半球比率（OEFHR），并利用QSM作为神经退行性变的中间标志物，来研究健康大脑与阿尔茨海默病（AD）受影响大脑之间半球不对称性的差异。估算结果及相应结果显示，健康受试者与AD患者之间存在虽微小但具有前景的差异。这些令人鼓舞的初步结果强调了进一步研究大脑结构不对称性及其改变作为AD相关神经退行性变潜在标志物的必要性。
英文摘要
Studying brain lateralization and the resulting hemispheric asymmetry has been a topic of interest for many researchers. Very few studies have focused on differences in brain lateralization and hemispheric asymmetry associated with neurodegeneration. Additionally, Quantitative Susceptibility Mapping (QSM) has not been extensively used to investigate these differences. This article aims to study differences in hemispheric asymmetry between healthy and Alzheimer's disease (AD)-affected brains by calculating the Myelin Hemispheric Ratio (MHR) and Oxygen Extraction Fraction Hemispheric Ratio (OEFHR) between the two hemispheres using QSM as an intermediate marker of neurodegeneration. The estimations and corresponding results show marginal yet promising differences between healthy subjects and AD patients. These encouraging initial results emphasize the need to further investigate structural brain asymmetry and its alteration as a potential marker of AD-related neurodegeneration.
