果蝇行走有多少是由线路连接决定的？
How much of fly walking is written in the wiring?
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中文总结 AI 辅助
本研究通过比较真实果蝇连接组与重布线网络，发现节律是通用的，但拮抗肌协调依赖特定线路，从而揭示连接组模型的线路连接重要性。
中文摘要 AI 辅助
果蝇神经索的连接组模型能够产生类似行走的运动节律，但仅凭振荡并不能证明特定的线路连接具有重要性。在此，我们提供了据我们所知的首个针对运动输出中哪些特征取决于特定线路连接的测试。我们模拟了两个独立的果蝇连接组的腿部运动系统，以突触数量作为固定权重，并将谷氨酸能突触视为抑制性突触，使用预先注册的标准，将每个系统与六类保留其结构越来越多特征的重新布线网络进行比较。我们发现节律是通用的，但拮抗肌协调并非如此：许多重新布线的网络比真实网络更具节律性，然而真实线路对拮抗运动池的协调强于所有重新布线的网络，尤其是在胸-基节关节处。我们将这种特异性追溯到前运动输入在拮抗运动池之间的分配方式。两个连接组都携带谢灵顿的交互神经支配——即兴奋一个运动池的神经元会抑制其拮抗运动池——而没有一个重新布线的网络如此。即使运动神经元的典型输入强度变化很小（在一个连接组中满足所有预先注册的标准；在另一个连接组中方向相同），在前运动输入在运动池之间重新分配后，协调性也被消除。因此，是协调性而非节律，揭示了连接组模型的线路连接是否重要。
英文摘要
Connectome models of the fly nerve cord generate walking-like motor rhythms, but oscillation alone does not show that the specific wiring matters. Here we provide, to our knowledge, the first test of which features of motor output depend on the specific wiring. We simulated the leg motor systems of two independent Drosophila connectomes, with synapse counts as fixed weights and glutamatergic synapses treated as inhibitory, and compared each with six families of rewired networks that preserve progressively more of its structure, using pre-registered criteria. We find that rhythm is generic but antagonist coordination is not: many rewired networks were more rhythmic than the real ones, yet the real wiring coordinated antagonistic motor pools more strongly than every rewired network, most of all at the thorax--coxa joint. We trace this specificity to how premotor input is allocated between antagonistic pools. Both connectomes carry Sherrington's reciprocal innervation---neurons that excite one pool inhibit its antagonist---and no rewired network does. Reassigning premotor inputs between the pools abolished coordination even when motor neurons' typical input strength changed little (all pre-registered criteria met in one connectome; same direction in the other). Coordination, not rhythm, therefore reveals whether a connectome model's wiring matters.
发表机构
- The Hong Kong University of Science and Technology（香港科技大学）
- ZENBOT
- Nanyang Technological University（南洋理工大学）
- The Hong Kong Polytechnic University（香港理工大学）
机构由 AI 辅助整理，请以论文原文为准。
