发表机构
Emerging Technologies Research Center, XPANCEO（新兴技术研究中心，XPANCEO）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本研究将分布式反馈激光器集成到隐形眼镜中，利用连续体束缚态实现高精度眼压监测，灵敏度达0.027 nm/mmHg，克服了传统光学传感器的精度限制。
AI 中文摘要
连续监测眼压（IOP）对于青光眼的诊断和管理至关重要，然而现有的临床方法依赖于间歇性的诊所内测量，这些测量会错过关键的昼夜波动。智能隐形眼镜是连续眼压追踪的一个有吸引力的平台，而光学应变传感器因其高灵敏度和自然读出方式而特别有前景。大多数此类光学传感器通过规则结构（光栅或光子晶体）的周期来推断应变，其变形通过光学方式读出。然而，所有基于规则结构周期的传感器的精度从根本上受到不确定性原理的限制，这严重限制了在隐形眼镜内部可用的毫米级尺度上的性能。在这里，我们通过将基于表面调制超薄F8BT染料层的分布式反馈（DFB）激光器集成到软质聚二甲基硅氧烷（PDMS）隐形眼镜中，来解决这一限制。该器件在Γ点的对称保护连续体束缚态下工作，产生窄线宽激光线，其波长随光栅应变直接移动——这一量不受空间不确定性原理的约束。DFB结构通过紫外全息光刻制造，并通过简单的浮脱工艺转移到镜片上，从而产生一种可拉伸、透明、与聚合物兼容且本质上可扩展的传感器。在定制的人工眼模型上进行测试，该模型的压力诱导变形尺度与人类眼睛报道的相当，传感器在幻影条件下实现了0.027 nm/mmHg的灵敏度和1.2 mmHg的校准残差，这一水平与眼压计监测相关，且具有很大的余量，目前主要受辅助读出设备的限制。
英文摘要
Continuous monitoring of intraocular pressure (IOP) is essential for the diagnosis and management of glaucoma, yet existing clinical methods rely on intermittent in-clinic measurements that miss critical diurnal fluctuations. Smart contact lenses are an attractive platform for continuous IOP tracking, and optical strain sensors are particularly promising thanks to their high sensitivity and natural readout. Most such optical sensors infer strain from the period of a regular structure - a grating or photonic crystal - whose deformation is read out optically. However, the precision of all sensors based on the period of regular structures is fundamentally bounded by the uncertainty principle, which severely limits performance at the millimeter length scales available inside a contact lens. Here, we address this limitation by integrating a distributed-feedback (DFB) laser, based on a surface-modulated ultrathin F8BT dye layer, into a soft polydimethylsiloxane (PDMS) contact lens. Operating at a symmetry-protected bound state in the continuum at the Γ point, the device produces a narrow lasing line whose wavelength shifts directly with grating strain - a quantity not constrained by the spatial uncertainty principle. The DFB structure is fabricated by UV holographic lithography and transferred onto the lens by a simple float-off process, yielding a stretchable, transparent, polymer-compatible sensor that is intrinsically scalable. Tested on a custom artificial eye model whose pressure-induced deformation is comparable in scale to that reported for the human eye, the sensor achieves a sensitivity of 0.027 nm/mmHg and a calibration residual of 1.2 mmHg under phantom conditions, a level relevant to tonometric monitoring, with substantial headroom currently limited mainly by auxiliary readout equipment.
