自组装过程中的剪切应力编码网络基材料的刚度
Shear stress during self-assembly encodes stiffness of network-based materials
- KU Leuven（荷语鲁汶大学）
- Forschungszentrum Jülich GmbH（于利希研究中心）
- Univ. Grenoble Alpes, CNRS, Grenoble INP, 3SR（格勒诺布尔阿尔卑斯大学、法国国家科学研究中心、格勒诺布尔理工学院、3SR实验室）
机构由 AI 辅助整理，请以论文原文为准。
中文总结 AI 辅助
该研究揭示在凝胶化过程中施加剪切应力可显著且不可逆地增强胶原蛋白网络刚度，其微观机制具有普遍性，为生物及合成网络弹性调控提供了通用原则。
中文摘要 AI 辅助
网络基材料的力学性能已在静止条件下得到广泛研究，然而它们在自然界中的自组装主要发生在机械应力环境中。在此，我们展示了胶原蛋白网络（哺乳动物细胞外基质的主要构建模块之一）的刚度可以通过在凝胶化过程中施加剪切应力来调节，该应力首先使材料应变并排列，然后触发弹性模量的剧烈不可逆增加。这种硬化通过维持应力直到凝胶完全成熟来锚定。使用基于粒子的模拟，我们表明潜在的微观机制可能对一大类网络基系统具有普遍性，并源于两种协同效应：通过形成稳定系统的永久接触，网络取向和拓扑结构发生变化。我们的发现通过刚性渗流框架进行了合理化，并为在生物和合成网络中编码弹性提供了一般原则。
英文摘要
The mechanical properties of network-based materials have been extensively studied under qui- escent conditions, yet their self-assembly in nature occurs mainly in a mechanically stressed envi- ronment. Here, we show that the stiffness of collagen networks, one of the main building blocks of the mammalian extracellular matrix, can be tuned by applying shear stress during gelation, which first strains and aligns the material, then triggers a dramatic irreversible increase in the elastic modulus. This stiffening is anchored by maintaining the stress until the gel is fully matured. Using particle-based simulations, we show that the underlying microscopic mechanism is likely generic to a broad class of network-based systems and arises from two synergetic effects: changes in the network orientation and topology through the formation of permanent contacts that stabilize the system. Our findings are rationalized using a rigidity percolation framework and offer a general principle for encoding elasticity in biological and synthetic networks.
