发表机构
National Central University; Academia Sinica（中央大学; 中央研究院）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
针对受体对极少数正确配体的快速特异反应，提出含结合态耦合和动力学校对的最小模型，发现单个正确配体可借错误配体诱导激活其他受体，实现快速灵敏响应。
AI 中文摘要
受T细胞受体对少量激动剂配体存在时反应的启发，我们提出了一个能够实现类似性能的最小模型。该模型由一小簇不可移动的受体组成，这些受体与环境中的两类（正确/错误）配体可逆结合，其中错误配体的结合强度略弱。模型具有最近邻受体之间的结合态耦合，处于结合/游离态的受体被特定酶激活/失活，其速率允许动力学校对。研究发现，在一定范围的结合态耦合强度下，仅错误配体无法激活受体，但仅仅一个正确配体与一个受体的结合就足以通过诱导结合错误配体来促进其他受体的激活。响应时间和信号放大均随受体结合态耦合强度的增加而增加，直至达到最佳范围，从而实现最快和最灵敏的响应。这些结果提示了一种可能的机制，即在亚细胞尺度上，生物和人工系统中受体对极少数正确配体能够做出快速且特异的反应。
英文摘要
Intrigued by the response of T cell receptors to the presence of a few agonist ligands, we propose a minimal model that can achieve similar performance. The model consists of a small cluster of immobile receptors that bind reversibly to two types (correct/incorrect) of ligands in the environment, with slightly weaker binding strength for the incorrect one. It features binding-state coupling between nearest-neighbor receptors, and receptors in the bound/free states are activated/deactivated by specific enzymes, with rates that allow kinetic proofreading. It is found that, for a range of binding-state coupling strength, incorrect ligands alone cannot activate the receptors, but the binding of merely one correct ligand to a receptor is sufficient to promote the activation of other receptors via induced binding to incorrect ligands. Both response time and signal amplification increase as the receptor binding-state coupling strength increases until it reaches an optimal range to achieve the most rapid and sensitive response. These results suggest a possible mechanism for a speedy and specific response of receptors to very few correct ligands in biological and artificial systems at the subcellular scale.
Comments5 figures. Version 3; a few typographical errors corrected
