流动、动力学与多细胞水力系统中的主动断裂
Flow, dynamics and active fracture in hydraulic multicellular systems
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中文总结 AI 辅助
本文提出统一细胞力学与流体流动的理论框架，揭示水力耦合调控组织渗透响应、流体通道及主动断裂，并通过斑马鱼胚胎实验验证水力抑制细胞运动，表明水力特性普遍影响多细胞系统行为。
中文摘要 AI 辅助
从组织间隙到管腔，流体压力和流动可以重塑、改造甚至重新定义生物组织。流体既可以主导细胞间的机械相互作用，也可以对其作出响应。然而，在细胞尺度上测量流动是困难的，这使得理解组织水力特性充满挑战。在此，我们开发了一种理论方法，将细胞力学和流体流动统一在一个框架中。我们发现，水力特性可以极大地影响组织行为。细胞形状和大小之间的水力耦合决定了组织对渗透冲击的响应，而调节组织的渗透性可以将流体引导至细胞之间或跨细胞膜流动。在活性组织中，水力特性可以抑制细胞迁移直至断裂，在此过程中我们发现了一种水力棘轮，它驱动流体从细胞中排出以产生小的管腔空间。我们通过实验证据表明，在注射增稠剂的斑马鱼早期胚胎中，水力特性可以抑制细胞运动，这表明水力特性可能普遍支配许多多细胞系统的行为。
英文摘要
From interstitial space to luminal cavities, fluid pressure and flow can remodel, reshape and even redefine a biological tissue. Fluids can either govern or react to mechanical interactions between cells. However, measuring flows at cellular scales is difficult, which makes it challenging to understand tissue hydraulics. Here, we develop a theoretical approach that captures cellular mechanics and fluid flow in one framework. We find that hydraulics can drastically influence tissue behavior. Hydraulic coupling between cell shape and size governs a tissue's response to osmotic shock, while tuning a tissue's permeabilities can channel fluid either between or across cell membranes. In active tissues, hydraulics can suppress cell mobility to the point of fracture, where we discover a hydraulic ratchet that drives fluid out of cells to generate small luminal spaces. We find experimental evidence that hydraulics can suppress cell motion in early stage zebrafish embryos injected with a thickening agent, which indicates that hydraulics may generally govern the behaviors of many multicellular systems.
发表机构
- Max Planck Institute for the Physics of Complex Systems（马克斯·普朗克复杂系统物理研究所）
- Center for Systems Biology Dresden（德累斯顿系统生物学中心）
- Max Planck Institute of Molecular Cell Biology and Genetics（马克斯·普朗克分子细胞生物学与遗传学研究所）
机构由 AI 辅助整理，请以论文原文为准。
