发表机构
Marathon Fusion（马拉松聚变）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
该研究提出利用聚变中子将钍、镤、镎转化为铅-212和锕-225发生器母体，实现规模化生产，满足靶向α疗法需求。
AI 中文摘要
靶向α疗法将需要大幅扩大${}^{212}$Pb和${}^{225}$Ac的生产。我们提出了中子驱动和光子驱动的路线，将${}^{230}$Th、${}^{231}$Pa、${}^{232}$Th和${}^{237}$Np转化为发生器母体${}^{228}$Th和${}^{229}$Th。最直接的${}^{225}$Ac路线是${}^{230}$Th(n,2n)${}^{229}$Th。一个10 MW的氘-氚（D-T）中子源，辐照含有27% ${}^{230}$Th同位素份额的钍，在六个月内积累约250 Ci的${}^{229}$Th，最初每年足以提供五百万个${}^{225}$Ac剂量当量，并且其7916年的半衰期使其在数千年内都有用。这仅需要约2吉瓦-天的D-T聚变运行。对数十克${}^{230}$Th进行热中子辐照可产生克量级的${}^{232}$U，这是一个持续数十年的${}^{228}$Th来源，每年可为数百万个${}^{212}$Pb剂量当量供源。替代路线通过${}^{231}$Pa进行：聚变中子从${}^{232}$Th每吉瓦-年产生1至2吨${}^{231}$Pa，而热反应堆每克${}^{231}$Pa可转化高达0.4 g的${}^{232}$U。每克储存的${}^{232}$U每年产生10 mg（8.2 Ci）的${}^{228}$Th。随后的${}^{228}$Th(n,$\gamma$)${}^{229}$Th反应每克${}^{228}$Th可转化0.07至0.34 g的${}^{229}$Th。我们还分析了${}^{237}$Np(n,2n)${}^{236\mathrm{m}}$Np路线到${}^{228}$Th。这些路径可从千瓦级扩展到兆瓦级D-T源，并可能每年确保数百万个${}^{212}$Pb和${}^{225}$Ac剂量当量的供应。
英文摘要
Targeted alpha therapy will require a large expansion of ${}^{212}$Pb and ${}^{225}$Ac production. We propose neutron- and photon-driven routes that convert ${}^{230}$Th, ${}^{231}$Pa, ${}^{232}$Th, and ${}^{237}$Np into generator parents ${}^{228}$Th and ${}^{229}$Th. The most direct ${}^{225}$Ac route is ${}^{230}$Th(n,2n)${}^{229}$Th. A 10 MW deuterium-tritium (D-T) neutron source irradiating thorium with a 27% ${}^{230}$Th isotopic fraction accumulates about 250 Ci of ${}^{229}$Th in six months, initially enough for five million ${}^{225}$Ac dose-equivalents per year, and its 7916 yr half-life makes it useful for millennia. This requires only $\sim$2 gigawatt-days of D-T fusion operations. Thermal-neutron irradiation of tens of grams of ${}^{230}$Th produces gram quantities of ${}^{232}$U, a decades-long source of ${}^{228}$Th for millions of ${}^{212}$Pb dose-equivalents per year. Alternate routes proceed through ${}^{231}$Pa: fusion neutrons produce 1 to 2 tonnes of ${}^{231}$Pa per gigawatt-year from ${}^{232}$Th, and a thermal reactor converts up to 0.4 g of ${}^{232}$U per gram of ${}^{231}$Pa. Each gram of stored ${}^{232}$U produces 10 mg (8.2 Ci) of ${}^{228}$Th per year. Subsequent ${}^{228}$Th(n,$γ$)${}^{229}$Th converts 0.07 to 0.34 g of ${}^{229}$Th per gram of ${}^{228}$Th. We also analyze the ${}^{237}$Np(n,2n)${}^{236\mathrm{m}}$Np route to ${}^{228}$Th. These pathways scale from kilowatt to megawatt D-T sources and could secure millions of ${}^{212}$Pb and ${}^{225}$Ac dose-equivalents per year.
Comments18 pages, 15 figures
