二维皮肤模型中涂层微针经皮胰岛素递送的数值模拟
Numerical Simulation of Transdermal Insulin Delivery Using a Coated Microneedle in a 2D Skin Model
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中文总结 AI 辅助
本研究提出一个计算模型，模拟涂层微针经皮递送胰岛素的过程，分析其在各皮肤层的传输与分布，并通过与实验数据对比验证模型的预测能力。
中文摘要 AI 辅助
在本工作中，我们提出了一个计算模型来研究使用涂层微针的经皮胰岛素递送。我们开发了一个包含涂层微针的详细皮肤几何结构，以分析胰岛素通过不同皮肤层的释放，并评估关键传输参数的影响。该模型代表了主要的皮肤层：角质层、活性表皮和真皮。我们使用非结构化网格以实现模型的可靠分辨率。模拟结果提供了对涂层微针中胰岛素渗透以及在不同皮肤层中的传输和分布的见解。最后，将模拟结果与实验数据进行比较，以评估模型的预测能力。
英文摘要
In this work, we present a computational model to investigate transdermal insulin delivery using coated microneedles. A detailed skin geometry incorporating a coated microneedles was developed to analyze insulin release through the different skin layers and to evaluate the influence of key transport parameters. The model represents the major skin layers: the stratum corneum, viable epidermis, and dermis. Unstructured grids were used to achieve a reliable resolution of the model. The simulations provide insights into the permeation of insulin from the coated microneedles and the transport and distribution across the different skin layers. Finally, the simulation results were compared with experimental data to evaluate the predictive capability of the model.
发表机构
- King Abdullah University of Science and Technology（阿卜杜拉国王科技大学）
- Goethe University（歌德大学）
机构由 AI 辅助整理，请以论文原文为准。
