发表机构
Texas Tech University; University of South Florida（德克萨斯理工大学; 南佛罗里达大学）
机构由 AI 辅助整理，请以论文原文为准。AI 中文总结
本研究通过形貌与阳离子工程调控铁氧体纳米颗粒，发现9.5 nm准立方Zn0.35Mn0.25Fe2.4O4兼具强加热、T2对比和血液相容性，适合静脉注射诊疗；大Fe3O4立方体则适用于瘤内热疗。
AI 中文摘要
将磁热疗与磁共振成像（MRI）相结合，需要纳米颗粒在全身给药后兼具强加热能力、T2对比度和血液相容性。本研究制备了柠檬酸盐稳定的铁氧体纳米颗粒（Fe3O4、Co0.6Fe2.4O4、Zn0.3Fe2.7O4和Zn0.35Mn0.25Fe2.4O4），形态包括球形（8-10.5 nm）和准立方体（9-12.5 nm），以及35 nm的Fe3O4立方体。通过将形貌工程与尖晶石晶格阳离子取代相结合，我们在临床兼容的交变磁场下，在卵巢肿瘤模拟体中调节了饱和磁化强度、矫顽力、T2加权信号衰减和热耗散。35 nm Fe3O4立方体和准立方体Zn0.35Mn0.25Fe2.4O4产生了最高的模拟体温度升高，而较小的球形颗粒产生较温和的加热。所有配方在SKOV3细胞中均具有细胞相容性，24小时活力大于96%。然而，血液相容性区分了领先候选者：35 nm Fe3O4立方体尽管溶血最小，但诱导了红细胞变形，而9 nm准立方体Zn0.35Mn0.25Fe2.4O4在高达1000 μg mL-1浓度下与PBS相比无变化。生理流动下的可灌注GelMA模型进一步证实了生物相容性。MRI模拟体显示，Fe3O4立方体产生延伸的信号空洞，可能模糊边界。总体而言，9.5 nm准立方体Zn0.35Mn0.25Fe2.4O4是领先的静脉注射候选者，兼具强加热、T2对比度和血液相容性，而大尺寸Fe3O4立方体更适合局部瘤内热疗。
英文摘要
Magnetic hyperthermia integrated with magnetic resonance imaging (MRI) requires nanoparticles that combine strong heating, T2 contrast, and hemocompatibility after systemic administration. Here, we prepared citrate-stabilized ferrite nanoparticles (Fe3O4, Co0.6Fe2.4O4, Zn0.3Fe2.7O4, and Zn0.35Mn0.25Fe2.4O4) in spherical (8-10.5 nm) and quasi-cubic (9-12.5 nm) forms, along with 35 nm Fe3O4 cubes. By coupling morphology engineering with spinel-lattice cation substitution, we tuned saturation magnetization, coercivity, T2-weighted signal attenuation, and heat dissipation in ovarian tumor-mimicking phantoms under clinically compatible alternating magnetic fields. The 35 nm Fe3O4 cube and quasi-cubic Zn0.35Mn0.25Fe2.4O4 generated the highest phantom temperature rises, whereas smaller spherical particles produced softer heating. All formulations were cytocompatible in SKOV3 cells, with >96% viability at 24 h. However, hemocompatibility distinguished the leading candidates: 35 nm Fe3O4 cubes induced red blood cell deformation despite minimal hemolysis, while 9 nm quasi-cubic Zn0.35Mn0.25Fe2.4O4 showed no change versus PBS up to 1,000 μg mL-1. Perfusable GelMA models under physiological flow further confirmed biocompatibility. MRI phantoms showed that Fe3O4 cubes produced extended signal voids that may obscure boundaries. Overall, 9.5 nm quasi-cubic Zn0.35Mn0.25Fe2.4O4 is the leading intravenous candidate, combining strong heating, T2 contrast, and hemocompatibility, whereas large Fe3O4 cubes are better suited for localized intratumoral hyperthermia.
Comments49 pages, 18 figures, 1 TOC graphic, 2 tables
