一种改善癫痫干预中海马体通路访问的MRI引导机器人系统
An MRI-Guided Robotic System to Improve Hippocampal Access for Epilepsy Interventions
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中文总结 AI 辅助
本文提出一种MRI引导的机器人系统，通过卵圆孔递送弯曲针状激光消融器，提高海马体插管百分比（实验达93.5%、96.5%、60.4%），优于临床直线LITT的50-60%，可治疗更大海马体积以改善癫痫控制。
中文摘要 AI 辅助
本文介绍了一种MRI引导的机器人系统，该系统通过卵圆孔（颅底的一个自然开口）递送弯曲的针状激光消融器，从而改善对海马体的通路访问。与当前临床使用的直线激光间质热疗（LITT）相比，该系统的递送路径和针的弯曲特性均提高了海马体插管百分比。我们描述了该机器人系统的设计，包括定位、瞄准和弯曲针部署阶段，随后展示了在体模中使用MRI图像评估插管百分比的实验结果。在三次曲线单次插入实验中，我们分别实现了93.5%、96.5%和60.4%的插管百分比，超过了报道的50-60%的临床平均水平。医生认为，癫痫控制效果与治疗的海马体体积相关，而我们的系统为基于LITT的干预提供了一种治疗更大体积海马体的手段。
英文摘要
This paper presents an MRI-guided robotic system that improves hippocampal access by delivering a curved needle-like laser ablator through the foramen ovale, a natural opening in the base of the skull. Both the delivery path and the curved nature of the needle improve upon current clinical straight-line laser interstitial thermal therapy (LITT) as measured by hippocampal cannulation percentage. We describe the design of the robotic system which includes positioning, aiming, and curved needle deployment stages, followed by experimental results assessing cannulation percentages using MRI images in phantoms. In three curvilinear, single-insertion experiments, we achieved cannulation percentages of 93.5%, 96.5%, and 60.4%, exceeding reported clinical averages of 50-60%. Seizure control is believed by physicians to be a function of hippocampal volume treated, and our system provides a means of treating a greater volume of the hippocampus with LITT-based interventions.
发表机构
- Vanderbilt University（范德堡大学）
- Case Western Reserve University（凯斯西储大学）
- Vanderbilt University Medical Center（范德堡大学医学中心）
- University of Louisville Health（路易斯维尔大学健康中心）
机构由 AI 辅助整理，请以论文原文为准。
