反极性细胞间黏附引发的集体运动紊乱
Antipolar Cell-cell Adhesion-causing Collective Motility Disorder
- Graduate School of Integral Life Science, Hiroshima University（广岛大学综合生命科学研究院）
- Graduate School of Medical Sciences, Nagoya City University（名古屋城市大学医学院）
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AI总结：
本研究采用细胞Potts模型，探究反极性细胞间黏附对集体细胞迁移的影响，发现其会引发集体运动紊乱并抑制集体迁移，特定运动强度下可发生脱钉转变，该紊乱可通过反极性黏附与运动持续性的协同作用解释。
AI中文摘要：
本研究旨在从理论上探究反极性细胞间黏附，即黏附位点位于迁移细胞前缘的对侧，作为一种不规则极性黏附候选物，其可诱导集体细胞迁移紊乱。我们采用细胞Potts模型，模拟反极性黏附对由细胞运动性驱动的集体迁移的影响。反极性黏附会引发集体运动紊乱，即便在无黏附时也存在集体运动的情况下，该紊乱仍会表现为运动方向的无序构型。因此，反极性黏附会抑制集体迁移，这与极性黏附的作用相反，极性黏附可加速细胞运动的定向细胞间有序性。在特定运动强度下，集体运动紊乱会发生脱钉转变，转变为集体运动。通过平均场近似，反极性黏附与运动持续性之间的协同作用可对该集体运动紊乱作出物理解释。
英文摘要：
In this study, we aim to theoretically investigate antipolar cell-cell adhesion, in which adhesion sites are located on the opposite side of the leading edge of migrating cells, as a candidate for irregularly polarized adhesion that induces disorder in collective cell migration. We employ the cellular Potts model to simulate the effects of antipolar adhesion on collective migration driven by cell motility. Antipolar adhesion induces a collective motility disorder, which exhibits a disordered configuration in the motility direction, even when collective motion occurs in the absence of adhesion. Consequently, antipolar adhesion inhibits collective migration. The effect is in contrast to that of polar adhesion, which accelerates the directional intercellular order of cell motility. At a specific motility strength, a depinning transition emerges from a collective motility disorder to a collective motion. The collective motility disorder can be physically explained by the cooperative effect between antipolar adhesion and motility persistence within the mean-field approximation.
