采用主动追踪点扫描光学相干断层扫描的空间或时间分辨基于相位的光视网膜成像技术
Spatially or temporally resolved phase-based optoretinography with actively-tracked point-scanning optical coherence tomography
- Medical Laser Center Lübeck GmbH（吕贝克医学激光中心有限公司）
- Institute of Biomedical Optics, University of Lübeck（吕贝克大学生物医学光学研究所）
- Heidelberg Engineering GmbH（海德堡工程有限公司）
- Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)（北气道研究中心（ARCN），德国肺病研究中心（DZL）成员）
机构由 AI 辅助整理，请以论文原文为准。
AI总结：
该研究采用主动追踪点扫描光学相干断层扫描，实现了空间或时间分辨的基于相位的光视网膜成像，降低了其临床转化的技术障碍。
AI中文摘要：
光视网膜成像是一种很有前景的视觉功能测量方法，但由于硬件要求苛刻，其临床转化仍局限于研究场景。在此，我们证明使用常规点扫描光谱域光学相干断层扫描即可实现高质量的基于相位的光视网膜成像。我们表明，通过对一致空间位置的相位变化进行精确采样，可规避对高成像速度的需求。在过滤掉非定位B扫描后，在固定位置采集的B扫描序列中可实现光诱发外段伸长的时间分辨，而在低至1Hz速率采集的体积数据中可实现空间分辨。这些结果表明，基于相位的光视网膜成像的技术障碍远低于此前假设，为其广泛临床转化铺平了道路。
英文摘要：
Optoretinography is a promising approach to measure visual function but its clinical translation has remained confined to research settings due to demanding hardware requirements. Here, we demonstrate that high-quality phase-based optoretinography can be performed using conventional point-scanning spectral-domain optical coherence tomography. We show that the need for high imaging speed can be circumvented by accurate sampling of phase changes at consistent spatial location. Light-evoked outer-segment expansion could be temporally resolved in B-scan series acquired at a fixed position when filtering off-location B-scans, and spatially resolved in volumes acquired at rates as low as 1~Hz. These results indicate that the technical barrier for phase-based optoretinography is substantially lower than previously assumed and pave the way toward broad clinical translation.
