精神分裂症中40Hz听觉稳态反应异常的前端与后端计算建模
Front-end and Back-end Computational Modeling of 40-Hz Auditory Steady-State Response Abnormalities in Schizophrenia
- School of Mathematical Sciences, Jiangsu University（江苏大学数学科学学院）
机构由 AI 辅助整理，请以论文原文为准。
AI总结：
本研究通过构建听觉前端与威尔逊-考恩E/I模型耦合的系统，发现精神分裂症的40Hz ASSR降低可能源于感觉编码、皮层E/I动态改变或两者结合，其框架可支持患者水平机制比较与个体化分层。
AI中文摘要：
40Hz听觉稳态反应（ASSR）在精神分裂症患者中降低，但目前尚不清楚这反映的是听觉输入改变还是皮层兴奋/抑制（E/I）动态改变。我们假设，相似的组间差异可通过不同的模型机制产生。我们对21名健康对照（HC）和21名精神分裂症患者（SCZ）的脑电（EEG）伽马百分比（gamma%）和相位锁值（ITPC）进行约束，构建了一个听觉前端与威尔逊-考恩（Wilson-Cowan）E/I模型耦合的系统。我们比较了前端受限、后端受限及全联合参数搜索，还开展了扰动和不动点分析。HC的两项指标均值均高于SCZ（无单独显著性）。所有三种模型均再现了HC>SCZ的模式，但定位组间差异的方式不同：前端通过输入转换，后端通过皮层动态，全联合则通过两者结合。全联合解对扰动的鲁棒性最高。不动点分析显示，不同局部动态可产生相似输出。所有模型均再现了HC>SCZ的模式，提示精神分裂症病理生理学可能涉及感觉编码改变、皮层E/I改变或两者皆有。该框架为未来患者水平的机制比较提供了可能，经验证后或可支持个体化分层。
英文摘要：
40-Hz ASSR is reduced in schizophrenia, but it is unclear if this reflects altered auditory input or cortical E/I dynamics. We hypothesized that similar group differences could arise via distinct model mechanisms. EEG gamma% and ITPC from 21 HC and 21 SCZ constrained an auditory front-end coupled to a Wilson-Cowan E/I model. We compared front-end-restricted, back-end-restricted, and full-joint parameter searches, plus perturbation and fixed-point analyses. HC means exceeded SCZ for both metrics (not individually significant). All three models reproduced HC>SCZ but located group differences differently: front-end via input transformation, back-end via cortical dynamics, full-joint via both. The full-joint solution was most robust to perturbation. Fixed-point analysis revealed similar outputs with distinct local dynamics. All models reproduced the HC>SCZ pattern, suggesting schizophrenia pathophysiology may involve altered sensory encoding, altered cortical E/I, or both. This framework enables future patient-level mechanistic comparison and, after validation, may support individualized stratification.
